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Literature summary extracted from

  • Clarke, C.J.; Ohanian, V.; Ohanian, J.
    Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase (2007), Am. J. Physiol. Heart Circ. Physiol., 292, H2248-H2256.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.107 endothelin-1 activates diacylglycerol kinase in caveolae/rafts and noncaveolae/rafts of mesenteric arteries. Activation does not depend on phosphatidylinositol 3-kinase. In response to norepinephrin, but not to epithelin-1, protein kinase PKB translocates to caveolae/rafts Rattus norvegicus
2.7.1.107 norepinephrine stimulates an increase in diacylglycerol kinase activity in caveolae/rafts of mesenteric arteries. Activation depends on phosphatidylinositol 3-kinase. In response to norepinephrin, but not to epithelin-1, protein kinase PKB translocates to caveolae/rafts Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Rattus norvegicus PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1 ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Rattus norvegicus
-
-
-
2.7.1.137 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 mesenteric artery
-
 Rattus norvegicus
-
2.7.1.137 mesenteric artery
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 additional information PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 PI3-kinase
-
 Rattus norvegicus