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Literature summary extracted from

  • El Omari, K.; Dhaliwal, B.; Lockyer, M.; Charles, I.; Hawkins, A.R.; Stammers, D.K.
    Structure of Staphylococcus aureus guanylate monophosphate kinase (2006), Acta Crystallogr. Sect. F, F62, 949-953.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.4.8 Crystals grown in 20% PEG 3350, 0.2 M LiSO4 and 0.1 M Tris-HCl pH 8. Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.8 24000
-
 guanylate monophosphate kinase Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.8 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.8 dGMP + ATP Catalyses reversible phosphoryl transfer from a nucleotide donor to a nucleotide acceptor. Phosphorylation of (d)GMP to (d)GDP using ATP as phosphoryl donor. Guanylate monophosphate kinases are involved in the synthesis of nucleotide precursors, they indirectly modulate the synthesis of DNA and RNA. Staphylococcus aureus dGDP + ADP
-
 r
2.7.4.8 GMP + ATP Catalyses reversible phosphoryl transfer from a nucleotide donor to a nucleotide acceptor. Phosphorylation of (d)GMP to (d)GDP using ATP as phosphoryl donor. Guanylate monophosphate kinases are involved in the synthesis of nucleotide precursors, they indirectly modulate the synthesis of DNA and RNA. Staphylococcus aureus GDP + ADP
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.4.8 dimer One of the two SaGMK dimers within the crystal asymmetric unit has two monomers in different conformations: an open form with a bound sulfate ion (mimicking the beta-phosphate of ATP) and a closed form with bound GMP and sulfate ion. Each monomer is bound through its P-loop to a sulfate ion. Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
2.7.4.8 guanylate monophosphate kinase
-
 Staphylococcus aureus
2.7.4.8 Staphylococcus aureus guanylate monophosphate kinase
-
 Staphylococcus aureus