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Literature summary extracted from
- Dual activities of human prolidase (2006), Toxicol. In Vitro, 20, 71-77.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.8.2 | degradation | use of enzyme for decomposition of soman in vitro | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.8.2 | expression in Pichia pastoris | Homo sapiens |
| 3.4.13.9 | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.8.2 | extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.8.2 | 73000 | - |
x * 73000, SDS-PAGE | Homo sapiens |
| 3.4.13.9 | 73000 | - |
x * 73000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.8.2 | Homo sapiens | - |
bifunctional enzyme exhibiting additionally prolidase activity, E.C. 3.4.13.9 | - |
| 3.4.13.9 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.8.2 | glycoprotein | N-glycosylation at amino acids 13 and 171 | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.13.9 | liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.9 | 21500 | - |
pH 7.8, 37°C | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.8.2 | additional information | additional substrate: dipeptide Gly-Pro, prolidase activity of enzyme | Homo sapiens | ? | - |
? |  |
| 3.1.8.2 | soman + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.13.9 | Gly-L-Pro + H2O | - |
Homo sapiens | Gly + L-Pro | - |
? | |
| 3.4.13.9 | additional information | enzyme additionally hydrolyzes organophosphorous compounds like soman | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.8.2 | ? | x * 73000, SDS-PAGE | Homo sapiens |
| 3.4.13.9 | ? | x * 73000, SDS-PAGE | Homo sapiens |
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