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Literature summary extracted from

  • Quistad, G.B.; Fisher, K.J.; Owen, S.C.; Klintenberg, R.; Casida, J.E.
    Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates (2005), Toxicol. Appl. Pharmacol., 205, 149-156.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 2-N-methylcarbamyl platelet-activating factor weak inhibition Homo sapiens
3.1.1.47 2-N-methylcarbamyl platelet-activating factor weak inhibition Mus musculus
3.1.1.47 benzodioxaphosphorin 2-oxides weak or no inhibition Homo sapiens
3.1.1.47 benzodioxaphosphorin 2-oxides decyl-derivative shows the strongest inhibition among the benzodioxaphosphorin 2-oxides tested Mus musculus
3.1.1.47 chlorpyrifos oxon ethyl- and methyl-derivative Homo sapiens
3.1.1.47 chlorpyrifos oxon pentyl- ethyl- and methyl-derivative Mus musculus
3.1.1.47 diazoxon weak inhibition Homo sapiens
3.1.1.47 diazoxon weak inhibition Mus musculus
3.1.1.47 n-alkyl methylphosphonofluoridates derivatives with chain length C13-C18 are highly potent in vitro inhibitors Homo sapiens
3.1.1.47 n-alkyl methylphosphonofluoridates derivatives with chain length C8-C18 are highly potent in vitro inhibitors Mus musculus
3.1.1.47 Sulfonyl fluorides weak inhibition Homo sapiens
3.1.1.47 Sulfonyl fluorides weak inhibition Mus musculus
3.1.1.47 tribufos inhibition at 0.1 mM Homo sapiens
3.1.1.47 tribufos inhibition at 0.1 mM Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Mus musculus regulation of platelet-activating factor 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens regulation of platelet-activating factor 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-
3.1.1.47 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 blood
-
 Mus musculus
-
3.1.1.47 blood plasma
-
 Homo sapiens
-
3.1.1.47 brain
-
 Mus musculus
-
3.1.1.47 liver
-
 Mus musculus
-
3.1.1.47 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor Mus musculus 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Mus musculus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens