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Literature summary extracted from

  • Gibson, C.L.; La Rosa, S.; Ohta, K.; Boyle, P.H.; Leurquin, F.; Lemacon, A.; Suckling, C.J.
    The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I (2004), Tetrahedron, 60, 943-959.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 8-Azaguanine 43% inhibition at 2.9 mM Escherichia coli
3.5.4.16 8-ethoxycarbonyl-7-deazaguanine 78% inhibition at 2.9 mM Escherichia coli
3.5.4.16 8-methyl-7-deazaguanine 94% inhibition at 2.9 mM Escherichia coli
3.5.4.16 8-trifluoromethyl-7-deazaguanine 17% inhibition at 2.9 mM Escherichia coli
3.5.4.16 additional information synthesis and inhibitory potential of 7-deazaguanine derivatives on GTPCH I, inhibitory mechanism, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.16 GTP + H2O Escherichia coli first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.16 GTPCH I
-
 Escherichia coli
3.5.4.16 guanosine triphosphate cyclohydrolase I
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.16 26
-
 assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 8.5
-
 assay at Escherichia coli