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Literature summary extracted from
- Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: a basis for the design of specific inhibitors (2006), Structure, 14, 901-911.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.3.18 | medicine | structure-based development of specific DDAH-1 inhibitors that might be useful in the therapeutic treatment of NOS dysfunction-related diseases | Bos taurus |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.5.3.18 | by sitting drop vapor diffusion, at 1.08-2.0 A resolution and at pH 6.3 and pH 9.0 | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.3.18 | L-citrulline | - |
Bos taurus |  |
| 3.5.3.18 | L-homocysteine | - |
Bos taurus | |
| 3.5.3.18 | S-nitroso-L-homocysteine | - |
Bos taurus | |
| 3.5.3.18 | Zn2+ | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.3.18 | Bos taurus | P56965 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.3.18 | anion exchange chromatography and gel filtration chromatography | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.3.18 | brain | - |
Bos taurus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.3.18 | DDAH-1 | - |
Bos taurus |
| 3.5.3.18 | dimethylarginine dimethylaminohydrolase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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