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Literature summary extracted from

  • Kristan, K.; Krajnc, K.; Konc, J.; Gobec, S.; Stojan, J.; Lanisnik Rizner, T.
    Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase (2005), Steroids, 70, 626-635.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 3,5,7,4'-tetrahydroxyflavone IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
1.1.1.62 3,7-dihydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
1.1.1.62 3-hydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one; IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
1.1.1.62 5,7-dihydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
1.1.1.62 5-hydroxyflavone IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata
1.1.1.62 5-methoxyflavone IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata
1.1.1.62 coumestrol IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Curvularia lunata
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 17beta-hydroxyestra-4-en-3-one + NADP+
-
 Curvularia lunata estra-4-en-3,17-dione + NADPH + H+
-
 r

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.62 0.001
-
 IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 5,7-dihydroxyflavone
1.1.1.62 0.001
-
 IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 3-hydroxyflavone
1.1.1.62 0.001
-
 IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 5-hydroxyflavone
1.1.1.62 0.001
-
 IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one Curvularia lunata 3,7-dihydroxyflavone
1.1.1.62 0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 3-hydroxyflavone
1.1.1.62 0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata coumestrol
1.1.1.62 0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 5-methoxyflavone
1.1.1.62 0.001 0.005 IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione Curvularia lunata 3,5,7,4'-tetrahydroxyflavone