EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.22 | expression in Escherichia coli BL21 as His-tag fusion protein | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.22 | Mg2+ | 56% inhibition at 10 mM | Escherichia coli |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.22 | 0.14 | - |
glycoaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 0.15 | - |
benzaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 0.24 | - |
propionaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 4.5 | - |
phenylacetaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 15.2 | - |
acetaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.39 | 0.0056 | - |
hexanal | pH 7.5 | Escherichia coli | |
1.2.1.39 | 0.0066 | - |
Heptanal | pH 7.5 | Escherichia coli | |
1.2.1.39 | 0.008 | - |
benzaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 0.0116 | - |
phenylacetaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 0.035 | - |
NAD+ | pH 7.5, cosubstrate: propionaldehyde | Escherichia coli | |
1.2.1.39 | 0.07 | - |
propionaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 0.22 | - |
NADP+ | pH 7.5, cosubstrate: propionaldehyde | Escherichia coli | |
1.2.1.39 | 2.15 | - |
acetaldehyde | pH 7.5 | Escherichia coli |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.22 | 210000 | - |
gel-filtration | Escherichia coli |
1.2.1.39 | 210700 | - |
gel filtration | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.39 | phenylacetaldehyde + NAD+ + H2O | Escherichia coli | the enzyme participates in metabolism of phenylalanine | phenylacetate + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.22 | Escherichia coli | - |
- |
- |
1.2.1.39 | Escherichia coli | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.22 | Ni-affinity chromatography | Escherichia coli |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.22 | cell culture | - |
Escherichia coli | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.22 | acetaldehyde + NAD+ + H2O | - |
Escherichia coli | acetate + NADH + H+ | - |
? | |
1.2.1.22 | benzaldehyde + NAD+ + H2O | - |
Escherichia coli | benzoate + NADH + H+ | - |
? | |
1.2.1.22 | glycoaldehyde + NAD+ + H2O | - |
Escherichia coli | glycolate + NADH + H+ | - |
? | |
1.2.1.22 | phenylacetaldehyde + NAD+ + H2O | - |
Escherichia coli | phenylacetate + NADH + H+ | - |
? | |
1.2.1.22 | propionaldehyde + NAD+ + H2O | - |
Escherichia coli | propionate + NADH + H+ | - |
? | |
1.2.1.39 | acetaldehyde + NAD+ + H2O | - |
Escherichia coli | acetate + NADH + H+ | - |
? | |
1.2.1.39 | benzaldehyde + NAD+ + H2O | - |
Escherichia coli | benzoate + NADH + H+ | - |
? | |
1.2.1.39 | heptanal + NAD+ + H2O | - |
Escherichia coli | heptanoate + NADH | - |
? | |
1.2.1.39 | hexanal + NAD+ + H2O | - |
Escherichia coli | hexanoate + NADH + H+ | - |
? | |
1.2.1.39 | phenylacetaldehyde + NAD+ + H2O | the enzyme participates in metabolism of phenylalanine | Escherichia coli | phenylacetate + NADH + H+ | - |
? | |
1.2.1.39 | phenylacetaldehyde + NAD+ + H2O | rate-limiting step is the hydride transfer | Escherichia coli | phenylacetate + NADH + H+ | - |
? | |
1.2.1.39 | phenylacetaldehyde + NADP+ + H2O | - |
Escherichia coli | phenylacetate + NADPH + H+ | - |
? | |
1.2.1.39 | propionaldehyde + NAD+ + H2O | - |
Escherichia coli | propionate + NADH | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.22 | tetramer | calculated from sequence, gel-filtration | Escherichia coli |
1.2.1.39 | tetramer | - |
Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.22 | ALD | - |
Escherichia coli |
1.2.1.22 | Lactaldehyde dehydrogenase | - |
Escherichia coli |
1.2.1.39 | PAD | - |
Escherichia coli |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.22 | 0.5 | - |
phenylacetaldehyd | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 0.6 | - |
acetaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 0.9 | - |
benzaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 1.8 | - |
propionaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.22 | 18.3 | - |
glycoaldehyde | 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ | Escherichia coli | |
1.2.1.39 | 0.16 | - |
benzaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 3.5 | - |
NAD+ | pH 7.5, cosubstrate: propionaldehyde | Escherichia coli | |
1.2.1.39 | 9 | - |
NADP+ | pH 7.5, cosubstrate: propionaldehyde | Escherichia coli | |
1.2.1.39 | 14.5 | - |
acetaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 20.17 | - |
NAD+ | pH 7.5, cosubstrate: propionaldehyde | Escherichia coli | |
1.2.1.39 | 20.8 | - |
propionaldehyde | pH 7.5 | Escherichia coli | |
1.2.1.39 | 21.8 | - |
hexanal | pH 7.5 | Escherichia coli | |
1.2.1.39 | 26.7 | - |
Heptanal | pH 7.5 | Escherichia coli | |
1.2.1.39 | 96.8 | - |
phenylacetaldehyde | pH 7.5 | Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.22 | NAD+ | - |
Escherichia coli | |
1.2.1.39 | NAD+ | active with NAD+ and NADP+, preference for NAD+. kcat/Km for NAD+ with propionaldehyde as cosubstrate is 34700 | Escherichia coli | |
1.2.1.39 | NADP+ | active with NAD+ and NADP+, preference for NAD+. kcat/Km for NADP+ with propionaldehyde is 2460 | Escherichia coli |