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Literature summary extracted from

  • Rodriguez-Zavala, J.S.; Allali-Hassani, A.; Weiner, H.
    Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases (2006), Protein Sci., 15, 1387-1396.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.22 expression in Escherichia coli BL21 as His-tag fusion protein Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.22 Mg2+ 56% inhibition at 10 mM Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.22 0.14
-
glycoaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 0.15
-
benzaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 0.24
-
propionaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 4.5
-
phenylacetaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 15.2
-
acetaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.39 0.0056
-
hexanal pH 7.5 Escherichia coli
1.2.1.39 0.0066
-
Heptanal pH 7.5 Escherichia coli
1.2.1.39 0.008
-
benzaldehyde pH 7.5 Escherichia coli
1.2.1.39 0.0116
-
phenylacetaldehyde pH 7.5 Escherichia coli
1.2.1.39 0.035
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
1.2.1.39 0.07
-
propionaldehyde pH 7.5 Escherichia coli
1.2.1.39 0.22
-
NADP+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
1.2.1.39 2.15
-
acetaldehyde pH 7.5 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.22 210000
-
gel-filtration Escherichia coli
1.2.1.39 210700
-
gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.39 phenylacetaldehyde + NAD+ + H2O Escherichia coli the enzyme participates in metabolism of phenylalanine phenylacetate + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.22 Escherichia coli
-
-
-
1.2.1.39 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.22 Ni-affinity chromatography Escherichia coli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.22 cell culture
-
Escherichia coli
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.22 acetaldehyde + NAD+ + H2O
-
Escherichia coli acetate + NADH + H+
-
?
1.2.1.22 benzaldehyde + NAD+ + H2O
-
Escherichia coli benzoate + NADH + H+
-
?
1.2.1.22 glycoaldehyde + NAD+ + H2O
-
Escherichia coli glycolate + NADH + H+
-
?
1.2.1.22 phenylacetaldehyde + NAD+ + H2O
-
Escherichia coli phenylacetate + NADH + H+
-
?
1.2.1.22 propionaldehyde + NAD+ + H2O
-
Escherichia coli propionate + NADH + H+
-
?
1.2.1.39 acetaldehyde + NAD+ + H2O
-
Escherichia coli acetate + NADH + H+
-
?
1.2.1.39 benzaldehyde + NAD+ + H2O
-
Escherichia coli benzoate + NADH + H+
-
?
1.2.1.39 heptanal + NAD+ + H2O
-
Escherichia coli heptanoate + NADH
-
?
1.2.1.39 hexanal + NAD+ + H2O
-
Escherichia coli hexanoate + NADH + H+
-
?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O the enzyme participates in metabolism of phenylalanine Escherichia coli phenylacetate + NADH + H+
-
?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O rate-limiting step is the hydride transfer Escherichia coli phenylacetate + NADH + H+
-
?
1.2.1.39 phenylacetaldehyde + NADP+ + H2O
-
Escherichia coli phenylacetate + NADPH + H+
-
?
1.2.1.39 propionaldehyde + NAD+ + H2O
-
Escherichia coli propionate + NADH
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.22 tetramer calculated from sequence, gel-filtration Escherichia coli
1.2.1.39 tetramer
-
Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.2.1.22 ALD
-
Escherichia coli
1.2.1.22 Lactaldehyde dehydrogenase
-
Escherichia coli
1.2.1.39 PAD
-
Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.22 0.5
-
phenylacetaldehyd 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 0.6
-
acetaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 0.9
-
benzaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 1.8
-
propionaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.22 18.3
-
glycoaldehyde 100 mM H2NaPO4 pH 7.5, 100 mM NaCl, 20 mM 2-mercaptoethanol, 2 mM NAD+ Escherichia coli
1.2.1.39 0.16
-
benzaldehyde pH 7.5 Escherichia coli
1.2.1.39 3.5
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
1.2.1.39 9
-
NADP+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
1.2.1.39 14.5
-
acetaldehyde pH 7.5 Escherichia coli
1.2.1.39 20.17
-
NAD+ pH 7.5, cosubstrate: propionaldehyde Escherichia coli
1.2.1.39 20.8
-
propionaldehyde pH 7.5 Escherichia coli
1.2.1.39 21.8
-
hexanal pH 7.5 Escherichia coli
1.2.1.39 26.7
-
Heptanal pH 7.5 Escherichia coli
1.2.1.39 96.8
-
phenylacetaldehyde pH 7.5 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.22 NAD+
-
Escherichia coli
1.2.1.39 NAD+ active with NAD+ and NADP+, preference for NAD+. kcat/Km for NAD+ with propionaldehyde as cosubstrate is 34700 Escherichia coli
1.2.1.39 NADP+ active with NAD+ and NADP+, preference for NAD+. kcat/Km for NADP+ with propionaldehyde is 2460 Escherichia coli