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Literature summary extracted from
- Isoenzymatic forms of human cytidine deaminase (2004), Protein Eng. Des. Sel., 17, 871-877.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.5 | (cytidyl)acryloylaminohexanoic acid | i.e. CV6 | Homo sapiens |  |
| 3.5.4.5 | 3,4,5,6-Tetrahydrouridine | - |
Homo sapiens | |
| 3.5.4.5 | 5,6-Dihydrouridine | - |
Homo sapiens | |
| 3.5.4.5 | 5-fluorozebularine | - |
Homo sapiens | |
| 3.5.4.5 | cytidine monophosphate | - |
Homo sapiens | |
| 3.5.4.5 | uridine | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.5 | 0.03 | - |
2'-deoxycytidine | native enzyme, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.04 | - |
cytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.04 | - |
2'-deoxycytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.042 | - |
2'-deoxycytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.042 | - |
cytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.087 | - |
5-iododeoxycytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.1 | - |
5-iododeoxycytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.11 | - |
cytosine arabinoside | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.15 | - |
cytosine arabinoside | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.28 | - |
5-azacytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.31 | - |
5-azacytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.5 | 15000 | - |
4 * 15000, SDS-PAGE | Homo sapiens |
| 3.5.4.5 | 60000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | placenta | different arrangement of subunit isoforms CDA1 and CDA2 results in five isoforms differing only in isoelectric point, native and recombinant enzyme | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | 2'-deoxycytidine + H2O | - |
Homo sapiens | 2'-deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | 5-azacytidine + H2O | - |
Homo sapiens | 5-azauridine + NH3 | - |
? | |
| 3.5.4.5 | 5-iododeoxycytidine + H2O | - |
Homo sapiens | 5-iododeoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Homo sapiens | uridine arabinoside + NH3 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.5.4.5 | tetramer | 4 * 15000, SDS-PAGE | Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.5 | 0.00006 | - |
5-fluorozebularine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.0003 | - |
5-fluorozebularine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.007 | - |
3,4,5,6-Tetrahydrouridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.007 | - |
3,4,5,6-Tetrahydrouridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.015 | - |
5,6-Dihydrouridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.034 | - |
(cytidyl)acryloylaminohexanoic acid | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.04 | - |
5,6-Dihydrouridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.045 | - |
(cytidyl)acryloylaminohexanoic acid | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.3 | - |
cytidine monophosphate | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.31 | - |
uridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.31 | - |
uridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
| 3.5.4.5 | 0.39 | - |
cytidine monophosphate | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.5.4.5 | Homo sapiens | tetramer of recombinant subunit CDA2, isoelectric focusing | - |
4.5 |
| 3.5.4.5 | Homo sapiens | 5 different isoforms of native enzyme, isoelectric focusing | 4.9 | 4.55 |
| 3.5.4.5 | Homo sapiens | tetramer of recombinant subunit CDA1, isoelectric focusing | - |
5 |
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