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Literature summary extracted from

  • Chai, S.Y.; Fernando, R.; Ye, S.; Peck, G.R.; Albiston, A.L.
    Insulin-regulated aminopeptidase (2004), Proteases in Biology and Disease (Hooper, N. M. ; Lendeckel, U. , eds. ) Springer, 2, 61-81.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.3
-
Homo sapiens
3.4.11.3
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.3 cytoplasmic vesicle GLUT4-containing. Insulin-regulated aminopeptidase is a marker protein for specialized vesicles containing the insulin-responsive glucose transporter, GLUT4. The enzyme is thought to be involved in the tethering of GLUT4 vesicles to intracellular compartments Homo sapiens 31410
-
3.4.11.3 cytosol P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells Homo sapiens 5829
-
3.4.11.3 membrane the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity by posttranslational proteolytic cleavage between Phe154 and Ala155. P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells Homo sapiens 16020
-
3.4.11.3 plasma membrane translocated with GLUT4 to the plasma membrane unedr insulin stimulation Homo sapiens 5886
-
3.4.11.3 soluble the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.3 oxytocin + H2O Homo sapiens in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Bos taurus
-
-
-
3.4.11.3 Homo sapiens
-
-
-
3.4.11.3 Mus musculus
-
-
-
3.4.11.3 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.3 proteolytic modification the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity by posttranslational proteolytic cleavage between Phe154 and Ala155 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.3
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 adrenal gland membrane Bos taurus
-
3.4.11.3 brain
-
Mus musculus
-
3.4.11.3 epididymis
-
Rattus norvegicus
-
3.4.11.3 fat pad
-
Rattus norvegicus
-
3.4.11.3 placenta expressed in differentiated trophoblasts Homo sapiens
-
3.4.11.3 placenta in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus Homo sapiens
-
3.4.11.3 trophoblast differentiated Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 angiotensin III + H2O
-
Homo sapiens ?
-
?
3.4.11.3 additional information involvement of the enzyme in memory processing. AT4 ligands, upon binding to the catalytic site of insulin-regulated aminopeptidase, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia Homo sapiens ?
-
?
3.4.11.3 oxytocin + H2O in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus Homo sapiens ?
-
?
3.4.11.3 oxytocin + H2O cleavage sites: Cys-/-Tyr-/-Ile-/-Gln-/-Asn-/-Cys-Pro-Leu-Gly-NH2 Homo sapiens ?
-
?
3.4.11.3 oxytocin + H2O cleavage sites: Cys-/-Tyr-/-Phe-/-Gln-Asn-Cys-Pro-Arg-Gly-NH2 Homo sapiens ?
-
?
3.4.11.3 oxytocin + H2O enzyme opens the N-terminal cystine loop of oxytocin Homo sapiens ?
-
?
3.4.11.3 somatostatin + H2O
-
Mus musculus ?
-
?
3.4.11.3 Vasopressin + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.3 AT4 receptor
-
Mus musculus
3.4.11.3 AT4 receptor
-
Homo sapiens
3.4.11.3 AT4 receptor
-
Rattus norvegicus
3.4.11.3 AT4 receptor
-
Bos taurus
3.4.11.3 cystine aminopeptidase
-
Homo sapiens
3.4.11.3 insulin-regulated aminopeptidase
-
Mus musculus
3.4.11.3 insulin-regulated aminopeptidase
-
Homo sapiens
3.4.11.3 insulin-regulated aminopeptidase
-
Rattus norvegicus
3.4.11.3 insulin-regulated aminopeptidase
-
Bos taurus
3.4.11.3 IRAP
-
Mus musculus
3.4.11.3 IRAP
-
Homo sapiens
3.4.11.3 IRAP
-
Rattus norvegicus
3.4.11.3 IRAP
-
Bos taurus
3.4.11.3 oxytocinase
-
Mus musculus
3.4.11.3 oxytocinase
-
Homo sapiens
3.4.11.3 oxytocinase
-
Rattus norvegicus
3.4.11.3 oxytocinase
-
Bos taurus
3.4.11.3 P-LAP
-
Homo sapiens
3.4.11.3 Placental leucine aminopeptidase
-
Mus musculus
3.4.11.3 Placental leucine aminopeptidase
-
Homo sapiens
3.4.11.3 Placental leucine aminopeptidase
-
Rattus norvegicus
3.4.11.3 Placental leucine aminopeptidase
-
Bos taurus