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Literature summary extracted from

  • Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
    Thionein can serve as a reducing agent for the methionine sulfoxide reductases (2006), Proc. Natl. Acad. Sci. USA, 103, 8656-8661.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin Escherichia coli the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin Homo sapiens the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.B3 Homo sapiens Q8IXL7
-
-
1.8.4.B3 Homo sapiens Q9Y3D2
-
-
1.8.4.12 Escherichia coli
-
-
-
1.8.4.12 Homo sapiens
-
 isozyme MsrB2
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.4.12 peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin catalytic mechanism and the role of cofactor recycling in vivo Escherichia coli
a
1.8.4.12 peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin catalytic mechanism and the role of cofactor recycling in vivo Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.B3 L-methionine (R)-S-sulfoxide + dithiothreitol
-
 Homo sapiens L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.B3 L-methionine (R)-S-sulfoxide + thionein
-
 Homo sapiens L-methionine + thionein disulfide + H2O
-
 ?
1.8.4.B3 L-methionine (R)-S-sulfoxide + thioredoxin reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol Homo sapiens L-methionine + thioredoxin disulfide
-
 ?
1.8.4.B3 L-methionine (R)-S-sulfoxide + thioredoxin reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.B3 L-methionine (R)-sulfoxide + dithiothreitol
-
 Homo sapiens L-methionine + dithiothreitol disulfide
-
 ?
1.8.4.B3 additional information zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein Homo sapiens ?
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + DTT
-
 Escherichia coli L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + DTT
-
 Homo sapiens L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin
-
 Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.B3 hMsrB2
-
 Homo sapiens
1.8.4.B3 hMsrB3
-
 Homo sapiens
1.8.4.12 MsrB
-
 Escherichia coli
1.8.4.12 MsrB
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 dithiothreitol can act as cofactor only in vitro showing a much higher activity than thioredoxin Homo sapiens
1.8.4.12 dithiothreitol can substitute for thioredoxin in vitro Escherichia coli
1.8.4.12 thioredoxin natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview Homo sapiens
1.8.4.12 thioredoxin preferred and natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview Escherichia coli