Any feedback?
Literature summary extracted from
- Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis (2005), Pathophysiol. Haemost. Thromb., 33, 375-381.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | additional information | enzyme disorder phenotype, overview | Homo sapiens |
| 3.4.17.20 | additional information | enzyme-deficient mice phenotype, overview | Mus musculus |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.4.17.20 | activateds TAFI, TAFI, is unstable and highly sensitive to temperature | Mus musculus |
| 3.4.17.20 | activateds TAFI, TAFI, is unstable and highly sensitive to temperature | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.17.20 | extracellular | - |
Mus musculus | - |
- |
| 3.4.17.20 | extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | fibrin + H2O | Mus musculus | cleavage of C-terminal Lys, regulation, overview | fibrin + Lys | the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview | ? |  |
| 3.4.17.20 | fibrin + H2O | Homo sapiens | cleavage of C-terminal Lys, regulation, overview | fibrin + Lys | the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview | ? | |
| 3.4.17.20 | additional information | Mus musculus | the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview | ? | - |
? | |
| 3.4.17.20 | additional information | Homo sapiens | the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | Homo sapiens | - |
- |
- |
| 3.4.17.20 | Mus musculus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | proteolytic modification | the enzyme is synthesized as zymogen, activation of TAFI by thrombin to TAFIa, inactivation of TAFIa by cleavage through thrombin at Arg302 | Mus musculus |
| 3.4.17.20 | proteolytic modification | the enzyme is synthesized as zymogen, activation of TAFI by thrombin to TAFIa, inactivation of TAFIa by cleavage through thrombin at Arg302 | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | blood plasma | - |
Mus musculus | - |
| 3.4.17.20 | blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | fibrin + H2O | cleavage of C-terminal Lys, regulation, overview | Mus musculus | fibrin + Lys | the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview | ? | |
| 3.4.17.20 | fibrin + H2O | cleavage of C-terminal Lys, regulation, overview | Homo sapiens | fibrin + Lys | the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview | ? | |
| 3.4.17.20 | fibrin + H2O | cleavage of C-terminal Lys | Mus musculus | fibrin + Lys | - |
? | |
| 3.4.17.20 | fibrin + H2O | cleavage of C-terminal Lys | Homo sapiens | fibrin + Lys | - |
? | |
| 3.4.17.20 | additional information | the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview | Mus musculus | ? | - |
? | |
| 3.4.17.20 | additional information | the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | Carboxypeptidase R | - |
Mus musculus |
| 3.4.17.20 | Carboxypeptidase R | - |
Homo sapiens |
| 3.4.17.20 | Plasma carboxypeptidase B | - |
Mus musculus |
| 3.4.17.20 | Plasma carboxypeptidase B | - |
Homo sapiens |
| 3.4.17.20 | TAFI | - |
Mus musculus |
| 3.4.17.20 | TAFI | - |
Homo sapiens |
| 3.4.17.20 | thrombin activatable fibrinolysis inhibitor | - |
Mus musculus |
| 3.4.17.20 | thrombin activatable fibrinolysis inhibitor | - |
Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | 22 | - |
TAFIa half-life: 10 min | Mus musculus |
| 3.4.17.20 | 22 | - |
TAFIa half-life: 10 min | Homo sapiens |
| 3.4.17.20 | 22 | - |
TAFIa half-life: several hours | Mus musculus |
| 3.4.17.20 | 22 | - |
TAFIa half-life: several hours | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
