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Literature summary extracted from

  • Daniellou, R.; Phenix, C.P.; Tam, P.H.; Laliberte, M.C.; Palmer, D.R.
    Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis (2005), Org. Biomol. Chem., 3, 401-403.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.18 3
-
 methyl 4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoate 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 4
-
 (1S,2S,3R,4S,5S)-5-(benzyloxy)cyclohexane-1,2,3,4-tetrol 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 7
-
 (1S,2S,3R,4S,5S)-5-(allyloxy)cyclohexane-1,2,3,4-tetrol 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 8
-
 (1S,2S,3R,4S,5S)-5-methoxycyclohexane-1,2,3,4-tetrol 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 18
-
 myo-inositol 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 44
-
 4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoic acid 25°C, pH 9.0 Bacillus subtilis
1.1.1.18 57
-
 melibiose 25°C, pH 9.0 Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.18 Bacillus subtilis P26935
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.18 (1S,2S,3R,4S,5S)-5-(allyloxy)cyclohexane-1,2,3,4-tetrol + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 (1S,2S,3R,4S,5S)-5-(benzyloxy)cyclohexane-1,2,3,4-tetrol + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 (1S,2S,3R,4S,5S)-5-methoxycyclohexane-1,2,3,4-tetrol + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoic acid + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 melibiose + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 methyl 4-([[(1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl]oxy]methyl)benzoate + NAD+
-
 Bacillus subtilis ?
-
 ?
1.1.1.18 additional information a nonpolar cavity adjacent to the active site, allows racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high stereoselectivity. Trace activity with (1S,2S,3R,4S,5S)-2,3,4,5-tetrahydroxycyclohexyl dihydrogen phosphate Bacillus subtilis ?
-
 ?
1.1.1.18 myo-inositol + NAD+
-
 Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.18 NAD+
-
 Bacillus subtilis