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Literature summary extracted from

  • Saad, L.O.; Mirandola, S.R.; Maciel, E.N.; Castilho, R.F.
    Lactate dehydrogenase activity is inhibited by methylmalonate in vitro (2006), Neurochem. Res., 31, 541-548.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 3-nitropropionate
-
 Rattus norvegicus
1.1.1.27 methylmalonate
-
 Bos taurus
1.1.1.27 methylmalonate IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver) Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.27 1.79
-
 (S)-lactate
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Bos taurus
-
-
-
1.1.1.27 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 brain
-
 Rattus norvegicus
-
1.1.1.27 brain
-
 Bos taurus
-
1.1.1.27 heart
-
 Bos taurus
-
1.1.1.27 liver
-
 Rattus norvegicus
-
1.1.1.27 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 (S)-lactate + NAD+
-
 Rattus norvegicus pyruvate + NADH + H+
-
 ?
1.1.1.27 (S)-lactate + NAD+
-
 Bos taurus pyruvate + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NAD+
-
 Rattus norvegicus
1.1.1.27 NAD+
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.27 3.02
-
 methylmalonate enzyme from brain Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.27 4.6
-
 IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver) Rattus norvegicus methylmalonate