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Literature summary extracted from

  • Czegle, I.; Piccirella, S.; Senesi, S.; Csala, M.; Mandl, J.; Banhegyi, G.; Fulceri, R.; Benedetti, A.
    Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum (2006), Mol. Cell. Endocrinol., 248, 24-25.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 endoplasmic reticulum lumen Rattus norvegicus 5783
-
1.1.1.146 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1 might play an important role in the metabolic syndrome cortisol + NADP+
-
 r
1.1.1.146 additional information Rattus norvegicus isozyme 11beta-HSD1 and hexose-6-phosphate dehydrogenase are co-localized in the hepatic endoplasmic reticulum and act in close cooperation in generation of cofactors for each other, functional coupling, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1 Rattus norvegicus cortisol + NADP+
-
 r
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1 might play an important role in the metabolic syndrome Rattus norvegicus cortisol + NADP+
-
 r
1.1.1.146 additional information isozyme 11beta-HSD1 and hexose-6-phosphate dehydrogenase are co-localized in the hepatic endoplasmic reticulum and act in close cooperation in generation of cofactors for each other, functional coupling, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus
1.1.1.146 11betaHSD1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Rattus norvegicus
1.1.1.146 NADPH
-
 Rattus norvegicus