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Literature summary extracted from

  • Clair, T.; Koh, E.; Ptaszynska, M.; Bandle, R.W.; Liotta, L.A.; Schiffmann, E.; Stracke, M.L.
    L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin (2005), Lipids Health Dis., 4, 5-5.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.39 medicine tumor cell motility-stimulating factor Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 1,10-phenanthroline 0.5 mM Homo sapiens
3.1.4.39 D-histidine 15 mM, 75% inhibition Homo sapiens
3.1.4.39 EDTA 10-20 mM Homo sapiens
3.1.4.39 histidine methylester 15 mM, 65% inhibition Homo sapiens
3.1.4.39 histidineamide 15 mM, 20% inhibition Homo sapiens
3.1.4.39 L-histidine 15-20 mM, noncompetitive, 75% inhibition, inhibition can be reversed by 20fold lower concentrations of zinc or cobalt salts Homo sapiens
3.1.4.39 N-methyl histidine 15 mM, 30% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.39 0.47
-
 lysophosphatidylcholine in presence of 0.25 mM Zn2+ plus 10 mM L-histidine Homo sapiens
3.1.4.39 0.49
-
 lysophosphatidylcholine
-
 Homo sapiens
3.1.4.39 0.55
-
 lysophosphatidylcholine in presence of 0.25 mM Zn2+ Homo sapiens
3.1.4.39 0.66
-
 lysophosphatidylcholine in presence of 10 mM L-histidine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.39 prepared from a Vaccinia viral lysate through the concanavalin A-agarose step Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Homo sapiens
3.1.4.39 autotaxin
-
 Homo sapiens
3.1.4.39 LPLD
-
 Homo sapiens
3.1.4.39 lysophospholipase D
-
 Homo sapiens
3.1.4.39 NPP-2
-
 Homo sapiens