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Literature summary extracted from

  • Ayachi, S.E.; Paulmyer-Lacroix, O.; Verdier, M.; Alessi, M.C.; Dutour, A.; Grino, M.
    11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women (2006), J. Thromb. Haemost., 4, 621-627.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 glycyrrhetinic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Homo sapiens biological transformation of inactive cortisone to active cortisol cortisol + NADP+
-
 ?
1.1.1.146 additional information Homo sapiens isozyme 11beta-HSD1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1, PAI-1, in adipose tissue of obese women ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
 obese women
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 adipose tissue expression of isozyme 11beta-HSD1, in situ hybridization, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ biological transformation of inactive cortisone to active cortisol Homo sapiens cortisol + NADP+
-
 ?
1.1.1.146 additional information isozyme 11beta-HSD1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1, PAI-1, in adipose tissue of obese women Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADPH
-
 Homo sapiens