Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Niiya, M.; Uemura, M.; Zheng, X.W.; Pollak, E.S.; Dockal, M.; Scheiflinger, F.; Wells, R.G.; Zheng, X.L.
    Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo (2006), J. Thromb. Haemost., 4, 1063-1070.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.87 additional information CCl4 at concentration of 6.5 mM does not directly enhance the activity of ADAMTS-13 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.87 EDTA complete inhibition at 10 mM Rattus norvegicus
3.4.24.87 additional information CCl4 at concentration of 6.5 mM does not directly inhibit the activity of ADAMTS-13 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.87 195000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 hepatic stellate cell
-
 Rattus norvegicus
-
3.4.24.87 hepatic stellate cell the dramatically increased ADAMTS-13 protein and proteolytic activity in the activated hepatic stellate cells in vitro and in vivo may be important part of functions of activated hepatic stellate cells, perhaps by modulating the processes of liver regeneration or formation of liver fibrosis after various insults Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 fluorescent resonance energy transfer-von Willebrand factor 73 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.87 von Willebrand factor + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 a disintegrin and metalloprotease with thrombospondin-13
-
 Rattus norvegicus
3.4.24.87 ADAMTS-13
-
 Rattus norvegicus