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Literature summary extracted from

  • Brooks, J.D.; Thompson, L.U.
    Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells (2005), J. Steroid Biochem. Mol. Biol., 94, 461-467.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 enterodiol
-
 Homo sapiens
1.1.1.62 enterolactone 0.05 mM, 84% inhibition Homo sapiens
1.1.1.62 genistein 0.05 mM, 59% inhibition Homo sapiens
1.1.1.62 additional information modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 estrone + NAD(P)H + H+ Homo sapiens
-
 estradiol + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 MCF-7 cell modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 estrone + NAD(P)H + H+
-
 Homo sapiens estradiol + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD type 1
-
 Homo sapiens