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Literature summary extracted from

  • Vinson, S.M.; Rickard, A.; Ryerse, J.S.; McHowat, J.
    Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition (2005), J. Pharmacol. Exp. Ther., 314, 1241-1247.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 methyl arachidonyl fluorophosphonate potent inhibitor, IC50: 0.0003 mM, almost complete inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens regulation of platelet-activating factor, anti-inflammatory enzyme 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 HBMEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor, anti-inflammatory enzyme Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF-acetylhydrolase
-
 Homo sapiens
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.47 0.0003
-
 potent inhibitor, IC50: 0.0003 mM, almost complete inhibition at 0.01 mM Homo sapiens 1-amino-4-[phenanthrene-9-yl-amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate