Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Song, E.S.; Hersh, L.B.
    Insulysin: an allosteric enzyme as a target for Alzheimers disease (2005), J. Mol. Neurosci., 25, 201-206.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.56 bradykinin activation of reaction with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) and amyloid beta-protein Mus musculus
3.4.24.56 dynorphin A-17 activation of reaction with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) and amyloid beta-protein Mus musculus
3.4.24.56 dynorphin B-13 activation of reaction with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) and amyloid beta-protein Mus musculus
3.4.24.56 dynorphin B-9 activation of reaction with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) and amyloid beta-protein Mus musculus
3.4.24.56 Insulin B-chain activation of reaction with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) and amyloid beta-protein Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.56 additional information
-
 additional information with substrate 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine), enzyme exhibits allosteric kinetics Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Mus musculus
-
 enzyme-deficient strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain in enzyme-deficient strain, accumulation of amyloid beta-protein Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 2-aminobenzoyl-GGFLRKHGQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Mus musculus ?
-
 ?