EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.B40 | drug development | the enzyme is a target for inhibitor design and development | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.B40 | expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Rattus norvegicus |
1.1.1.B40 | expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Mesocricetus auratus |
1.1.1.B40 | expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells | Homo sapiens |
1.1.1.B40 | expression of isozyme 11beta-HSD1 in HEK-293 cells | Cavia porcellus |
1.1.1.B40 | isozyme 11beta-HSD1, expression in HEK-293 cells | Mus musculus |
1.1.1.B40 | isozyme 11beta-HSD1, expression in HEK-293 cells | Canis lupus familiaris |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | 2'-hydroxyflavanone | - |
Canis lupus familiaris | |
1.1.1.B40 | 2'-hydroxyflavanone | - |
Cavia porcellus | |
1.1.1.B40 | 2'-hydroxyflavanone | - |
Homo sapiens | |
1.1.1.B40 | 2'-hydroxyflavanone | - |
Mesocricetus auratus | |
1.1.1.B40 | 2'-hydroxyflavanone | - |
Mus musculus | |
1.1.1.B40 | 2'-hydroxyflavanone | - |
Rattus norvegicus | |
1.1.1.B40 | abietic acid | - |
Canis lupus familiaris | |
1.1.1.B40 | abietic acid | - |
Cavia porcellus | |
1.1.1.B40 | abietic acid | - |
Homo sapiens | |
1.1.1.B40 | abietic acid | - |
Mesocricetus auratus | |
1.1.1.B40 | abietic acid | - |
Mus musculus | |
1.1.1.B40 | abietic acid | - |
Rattus norvegicus | |
1.1.1.B40 | carbenoxolone | - |
Canis lupus familiaris | |
1.1.1.B40 | carbenoxolone | - |
Cavia porcellus | |
1.1.1.B40 | carbenoxolone | - |
Homo sapiens | |
1.1.1.B40 | carbenoxolone | - |
Mesocricetus auratus | |
1.1.1.B40 | carbenoxolone | - |
Mus musculus | |
1.1.1.B40 | carbenoxolone | - |
Rattus norvegicus | |
1.1.1.B40 | chenodeoxycholic acid | - |
Canis lupus familiaris | |
1.1.1.B40 | chenodeoxycholic acid | - |
Cavia porcellus | |
1.1.1.B40 | chenodeoxycholic acid | - |
Homo sapiens | |
1.1.1.B40 | chenodeoxycholic acid | - |
Mesocricetus auratus | |
1.1.1.B40 | chenodeoxycholic acid | - |
Mus musculus | |
1.1.1.B40 | chenodeoxycholic acid | - |
Rattus norvegicus | |
1.1.1.B40 | flavanone | - |
Canis lupus familiaris | |
1.1.1.B40 | flavanone | - |
Cavia porcellus | |
1.1.1.B40 | flavanone | - |
Homo sapiens | |
1.1.1.B40 | flavanone | - |
Mesocricetus auratus | |
1.1.1.B40 | flavanone | - |
Mus musculus | |
1.1.1.B40 | flavanone | - |
Rattus norvegicus | |
1.1.1.B40 | glycyrrhetinic acid | - |
Canis lupus familiaris | |
1.1.1.B40 | glycyrrhetinic acid | - |
Cavia porcellus | |
1.1.1.B40 | glycyrrhetinic acid | - |
Homo sapiens | |
1.1.1.B40 | glycyrrhetinic acid | - |
Mesocricetus auratus | |
1.1.1.B40 | glycyrrhetinic acid | - |
Mus musculus | |
1.1.1.B40 | glycyrrhetinic acid | - |
Rattus norvegicus | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Canis lupus familiaris | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Cavia porcellus | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Homo sapiens | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Mesocricetus auratus | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Mus musculus | |
1.1.1.B40 | additional information | inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL | Rattus norvegicus | |
1.1.1.B40 | T0504 | - |
Canis lupus familiaris | |
1.1.1.B40 | T0504 | - |
Cavia porcellus | |
1.1.1.B40 | T0504 | - |
Homo sapiens | |
1.1.1.B40 | T0504 | - |
Mesocricetus auratus | |
1.1.1.B40 | T0504 | - |
Mus musculus | |
1.1.1.B40 | T0504 | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.B40 | 0.00038 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mus musculus | |
1.1.1.B40 | 0.00042 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Homo sapiens | |
1.1.1.B40 | 0.00043 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Cavia porcellus | |
1.1.1.B40 | 0.00045 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.B40 | 0.00052 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mus musculus | |
1.1.1.B40 | 0.00052 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Homo sapiens | |
1.1.1.B40 | 0.00057 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.B40 | 0.00057 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Canis lupus familiaris | |
1.1.1.B40 | 0.00064 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Cavia porcellus | |
1.1.1.B40 | 0.00085 | - |
11-Dehydrocorticosterone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Rattus norvegicus | |
1.1.1.B40 | 0.00136 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Rattus norvegicus | |
1.1.1.B40 | 0.00157 | - |
cortisone | pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 | Canis lupus familiaris |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | 32000 | - |
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Cavia porcellus |
1.1.1.B40 | 33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mus musculus |
1.1.1.B40 | 33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Rattus norvegicus |
1.1.1.B40 | 33000 | - |
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mesocricetus auratus |
1.1.1.B40 | 35000 | - |
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Canis lupus familiaris |
1.1.1.B40 | 35000 | - |
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Mus musculus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Rattus norvegicus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Canis lupus familiaris | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Mesocricetus auratus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Homo sapiens | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | Cavia porcellus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | cortisol + NAD+ | Homo sapiens | isozyme 11beta-HSD2 | cortisone + NADH | - |
ir | |
1.1.1.B40 | cortisone + NADPH + H+ | Mus musculus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | Rattus norvegicus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | Canis lupus familiaris | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | Mesocricetus auratus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | Cavia porcellus | isozyme 11beta-HSD1, activation | cortisol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.B40 | Canis lupus familiaris | - |
poodle, isozyme 11beta-HSD1 | - |
1.1.1.B40 | Cavia porcellus | Q6QLL4 | isozyme 11beta-HSD1; gene HSD11B1, isozyme 11beta-HSD1 | - |
1.1.1.B40 | Homo sapiens | P28845 | isozyme 11beta-HSD2; isozyme 11beta-HSD2 | - |
1.1.1.B40 | Homo sapiens | P80365 | isozyme 11beta-HSD1; isozyme 11beta-HSD1 | - |
1.1.1.B40 | Mesocricetus auratus | Q6R0J2 | isozyme 11beta-HSD1; isozyme 11beta-HSD1 | - |
1.1.1.B40 | Mus musculus | - |
isozyme 11beta-HSD1 | - |
1.1.1.B40 | Rattus norvegicus | - |
isozyme 11beta-HSD1 | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Mus musculus | |
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Rattus norvegicus | |
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Canis lupus familiaris | |
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Mesocricetus auratus | |
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Homo sapiens | |
1.1.1.B40 | an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ | the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview | Cavia porcellus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.B40 | liver | - |
Canis lupus familiaris | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | additional information | - |
- |
Mus musculus |
1.1.1.B40 | additional information | - |
- |
Rattus norvegicus |
1.1.1.B40 | additional information | - |
- |
Canis lupus familiaris |
1.1.1.B40 | additional information | - |
- |
Mesocricetus auratus |
1.1.1.B40 | additional information | - |
- |
Homo sapiens |
1.1.1.B40 | additional information | - |
- |
Cavia porcellus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mus musculus | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Rattus norvegicus | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Canis lupus familiaris | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mesocricetus auratus | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Homo sapiens | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Cavia porcellus | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1, low activity | Canis lupus familiaris | corticosterone + NADP+ | - |
? | |
1.1.1.B40 | 2 7-oxocholesterol + 2 NADPH + 2 H+ | isozyme 11beta-HSD1, stereospecific reaction | Mesocricetus auratus | 7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+ | - |
? | |
1.1.1.B40 | 7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Mus musculus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
1.1.1.B40 | 7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Rattus norvegicus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
1.1.1.B40 | 7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Homo sapiens | 7beta-hydroxycholesterol + NADP+ | - |
? | |
1.1.1.B40 | 7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction, very low activity | Canis lupus familiaris | 7beta-hydroxycholesterol + NADP+ | - |
? | |
1.1.1.B40 | 7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction, very low activity | Cavia porcellus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
1.1.1.B40 | cortisol + NAD+ | isozyme 11beta-HSD2 | Homo sapiens | cortisone + NADH | - |
ir | |
1.1.1.B40 | cortisol + NAD+ | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | Homo sapiens | cortisone + NADH | - |
ir | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Mus musculus | cortisol + NADP+ | - |
r | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Rattus norvegicus | cortisol + NADP+ | - |
r | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Mus musculus | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Rattus norvegicus | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Canis lupus familiaris | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Mesocricetus auratus | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Homo sapiens | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, activation | Cavia porcellus | cortisol + NADP+ | - |
? | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, high activity | Mesocricetus auratus | cortisol + NADP+ | - |
r | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, high activity | Cavia porcellus | cortisol + NADP+ | - |
r | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, low activity | Canis lupus familiaris | cortisol + NADP+ | - |
r | |
1.1.1.B40 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, preferred substrate, high activity | Homo sapiens | cortisol + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.B40 | ? | x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Cavia porcellus |
1.1.1.B40 | ? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mus musculus |
1.1.1.B40 | ? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Rattus norvegicus |
1.1.1.B40 | ? | x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Mesocricetus auratus |
1.1.1.B40 | ? | x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Canis lupus familiaris |
1.1.1.B40 | ? | x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE | Homo sapiens |
1.1.1.B40 | More | structure molecular modeling | Mus musculus |
1.1.1.B40 | More | structure molecular modeling | Rattus norvegicus |
1.1.1.B40 | More | structure molecular modeling | Canis lupus familiaris |
1.1.1.B40 | More | structure molecular modeling | Mesocricetus auratus |
1.1.1.B40 | More | structure molecular modeling | Homo sapiens |
1.1.1.B40 | More | structure molecular modeling | Cavia porcellus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.B40 | 11beta-HSD1 | - |
Mus musculus |
1.1.1.B40 | 11beta-HSD1 | - |
Rattus norvegicus |
1.1.1.B40 | 11beta-HSD1 | - |
Canis lupus familiaris |
1.1.1.B40 | 11beta-HSD1 | - |
Mesocricetus auratus |
1.1.1.B40 | 11beta-HSD1 | - |
Homo sapiens |
1.1.1.B40 | 11beta-HSD1 | - |
Cavia porcellus |
1.1.1.B40 | 11beta-HSD2 | - |
Homo sapiens |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Canis lupus familiaris |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mesocricetus auratus |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Cavia porcellus |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
1.1.1.B40 | 7-alpha-HCD | - |
Mesocricetus auratus |
1.1.1.B40 | 7-alpha-hydroxycholesterol dehydrogenase | - |
Mesocricetus auratus |
1.1.1.B40 | corticosteroid 11-beta-dehydrogenase isozyme 1 | - |
Mesocricetus auratus |
1.1.1.B40 | corticosteroid 11-beta-dehydrogenase isozyme 1 | - |
Cavia porcellus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | 37 | - |
assay at | Mus musculus |
1.1.1.B40 | 37 | - |
assay at | Rattus norvegicus |
1.1.1.B40 | 37 | - |
assay at | Canis lupus familiaris |
1.1.1.B40 | 37 | - |
assay at | Mesocricetus auratus |
1.1.1.B40 | 37 | - |
assay at | Homo sapiens |
1.1.1.B40 | 37 | - |
assay at | Cavia porcellus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | 7.4 | - |
assay at | Mus musculus |
1.1.1.B40 | 7.4 | - |
assay at | Rattus norvegicus |
1.1.1.B40 | 7.4 | - |
assay at | Canis lupus familiaris |
1.1.1.B40 | 7.4 | - |
assay at | Mesocricetus auratus |
1.1.1.B40 | 7.4 | - |
assay at | Homo sapiens |
1.1.1.B40 | 7.4 | - |
assay at | Cavia porcellus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | NAD+ | - |
Homo sapiens | |
1.1.1.B40 | NADP+ | - |
Mus musculus | |
1.1.1.B40 | NADP+ | - |
Rattus norvegicus | |
1.1.1.B40 | NADP+ | - |
Canis lupus familiaris | |
1.1.1.B40 | NADP+ | - |
Mesocricetus auratus | |
1.1.1.B40 | NADP+ | - |
Homo sapiens | |
1.1.1.B40 | NADP+ | - |
Cavia porcellus | |
1.1.1.B40 | NADPH | - |
Mus musculus | |
1.1.1.B40 | NADPH | - |
Rattus norvegicus | |
1.1.1.B40 | NADPH | - |
Canis lupus familiaris | |
1.1.1.B40 | NADPH | - |
Mesocricetus auratus | |
1.1.1.B40 | NADPH | - |
Homo sapiens | |
1.1.1.B40 | NADPH | - |
Cavia porcellus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.B40 | 0.000006 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.000015 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.000025 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.000025 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.000028 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.00008 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.000082 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.00011 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.00012 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.00012 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.00023 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.00023 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.00025 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.00028 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.00029 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.0003 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.00033 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.00034 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.00035 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.00043 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.00044 | - |
glycyrrhetinic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.00055 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.00059 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.00077 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.00094 | - |
carbenoxolone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.0012 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.0018 | - |
T0504 | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.002 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.0021 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.0021 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.0021 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.0025 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.003 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.0039 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.0049 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.0049 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.0052 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.0061 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.0064 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.007 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.007 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.0097 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.011 | - |
abietic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.015 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.017 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction | Homo sapiens | |
1.1.1.B40 | 0.019 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.02 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.031 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction | Homo sapiens | |
1.1.1.B40 | 0.031 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Cavia porcellus | |
1.1.1.B40 | 0.034 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mus musculus | |
1.1.1.B40 | 0.035 | - |
chenodeoxycholic acid | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Mesocricetus auratus | |
1.1.1.B40 | 0.035 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Canis lupus familiaris | |
1.1.1.B40 | 0.05 | - |
2'-hydroxyflavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.054 | - |
flavanone | pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation | Rattus norvegicus | |
1.1.1.B40 | 0.2 | - |
flavanone | above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens | |
1.1.1.B40 | 0.2 | - |
2'-hydroxyflavanone | above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation | Homo sapiens |