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Literature summary extracted from

  • Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
    Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme (2005), J. Mol. Endocrinol., 35, 305-316.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in HEK-293 cells Homo sapiens
1.1.1.51 DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in zf4 cells Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.51 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.51 endoplasmic reticulum
-
 Danio rerio 5783
-
1.1.1.64 endoplasmic reticulum
-
 Danio rerio 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 androstenedione + NADPH + H+ Homo sapiens
-
 testosterone + NADP+
-
 r
1.1.1.51 androstenedione + NADPH + H+ Danio rerio
-
 testosterone + NADP+
-
 r
1.1.1.51 additional information Homo sapiens evolutionary considerations ?
-
 ?
1.1.1.51 additional information Danio rerio evolutionary considerations ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Danio rerio Q6QA32
-
-
1.1.1.51 Homo sapiens
-
-
-
1.1.1.64 Danio rerio
-
-
-
1.1.1.64 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 embryo enzyme expression during embryogenesis from sphere to 84 h post-fertilization Danio rerio
-
1.1.1.51 HEK-293 cell low expression level Homo sapiens
-
1.1.1.51 liver highest enzyme expression in male liver Danio rerio
-
1.1.1.51 additional information expression in female and male tissues, sexual dimorphism, no activity in zf4 cells Danio rerio
-
1.1.1.51 ovary highest enzyme expression in female ovaries Danio rerio
-
1.1.1.51 testis almost exclusively Homo sapiens
-
1.1.1.64 brain low activity in both sexes Danio rerio
-
1.1.1.64 embryo during embryogenesis the enzyme is present from the sphere stage until hatching Danio rerio
-
1.1.1.64 eye
-
 Danio rerio
-
1.1.1.64 heart expression in male, hardly detectable in female Danio rerio
-
1.1.1.64 intestine expression in male, hardly detectable in female Danio rerio
-
1.1.1.64 kidney expression in male, hardly detectable in female Danio rerio
-
1.1.1.64 liver
-
 Danio rerio
-
1.1.1.64 muscle
-
 Danio rerio
-
1.1.1.64 skin expression in male, hardly detectable in female Danio rerio
-
1.1.1.64 spleen expression in male, hardly detectable in female Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 11beta-hydroxyandrost-5-ene-3,17-dione + NADPH i.e. 11beta-hydroxy-androstenedione, reduction at C17 Homo sapiens 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ i.e. 11beta-testosterone ?
1.1.1.51 11beta-hydroxyandrost-5-ene-3,17-dione + NADPH i.e. 11beta-hydroxy-androstenedione, reduction at C17 Danio rerio 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ i.e. 11beta-testosterone ?
1.1.1.51 androst-5-ene-3,11,17-trione + NADPH i.e. 11-keto-androstenedione, reduction at C17 Danio rerio 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ i.e. 11-keto-testosterone ?
1.1.1.51 androst-5-ene-3,11,17-trione + NADPH i.e. 11-ketoandrostenedione, reduction at C17 Homo sapiens 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ i.e. 11-keto-testosterone ?
1.1.1.51 androstanedione + NADPH reduction at C17 Homo sapiens dihydrotestosterone + NADP+
-
 ?
1.1.1.51 androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 r
1.1.1.51 androstenedione + NADPH + H+
-
 Danio rerio testosterone + NADP+
-
 r
1.1.1.51 androstenedione + NADPH + H+ the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Homo sapiens testosterone + NADP+
-
 r
1.1.1.51 androstenedione + NADPH + H+ the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Danio rerio testosterone + NADP+
-
 r
1.1.1.51 androsterone + NADPH + H+ reduction at C17 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 dehydroepiandrosterone + NADPH + H+ reduction at C17 Homo sapiens 5-androstene-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 dehydroepiandrosterone + NADPH + H+ reduction at C17 Danio rerio 5-androstene-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 epiandrosterone + NADPH reduction at C17 Danio rerio androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 epiandrosterone + NADPH reduction at C17 Homo sapiens 5-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 additional information evolutionary considerations Homo sapiens ?
-
 ?
1.1.1.51 additional information evolutionary considerations Danio rerio ?
-
 ?
1.1.1.51 additional information no activity with androstanedione and androsterone Danio rerio ?
-
 ?
1.1.1.64 11-hydroxy-androstenedione + NADPH
-
 Homo sapiens 11beta-hydroxy-testosterone
-
 ?
1.1.1.64 11-hydroxy-androstenedione + NADPH
-
 Danio rerio 11beta-hydroxy-testosterone
-
 ?
1.1.1.64 11-ketoandrostenedione + NADPH
-
 Homo sapiens 11-ketotestosterone + NADP+
-
 ?
1.1.1.64 11-ketoandrostenedione + NADPH
-
 Danio rerio 11-ketotestosterone + NADP+
-
 ?
1.1.1.64 androstanedione + NADPH
-
 Homo sapiens dihydrotestosterone + NADP+
-
 ?
1.1.1.64 androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 r
1.1.1.64 androstenedione + NADPH + H+
-
 Danio rerio testosterone + NADP+
-
 r
1.1.1.64 androsterone + NADPH + H+
-
 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.64 dehydroepiandrosterone + NADPH
-
 Homo sapiens androst-5-en-3beta,17beta-diol + NADP+
-
 ?
1.1.1.64 dehydroepiandrosterone + NADPH
-
 Danio rerio androst-5-en-3beta,17beta-diol + NADP+
-
 ?
1.1.1.64 epiandrosterone + NADPH
-
 Homo sapiens androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.64 epiandrosterone + NADPH
-
 Danio rerio androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.64 testosterone + NAD+ NAD+ shows 20% of the activity with NADP+ Homo sapiens androstenedione + NADH
-
 ir
1.1.1.64 testosterone + NAD+ NAD+ shows ess than 10% of the activity with NADP+ Danio rerio androstenedione + NADH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD type 3
-
 Homo sapiens
1.1.1.51 17beta-HSD type 3
-
 Danio rerio
1.1.1.51 17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens
1.1.1.51 17beta-hydroxysteroid dehydrogenase type 3
-
 Danio rerio
1.1.1.64 17beta-HSD 3
-
 Homo sapiens
1.1.1.64 17beta-HSD 3
-
 Danio rerio
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 3
-
 Danio rerio

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 additional information no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Homo sapiens
1.1.1.51 additional information no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview Danio rerio
1.1.1.51 NADP+
-
 Homo sapiens
1.1.1.51 NADP+
-
 Danio rerio
1.1.1.51 NADPH
-
 Homo sapiens
1.1.1.51 NADPH
-
 Danio rerio
1.1.1.64 NAD+ 20% of the activity with NADP+, cosubstrate: testosterone Homo sapiens
1.1.1.64 NAD+ less than 10% of the activity with NADP+, cosubstrate: testosterone Danio rerio
1.1.1.64 NADP+
-
 Homo sapiens
1.1.1.64 NADP+
-
 Danio rerio
1.1.1.64 NADPH no activity with NADH Homo sapiens
1.1.1.64 NADPH no activity with NADH Danio rerio