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Literature summary extracted from

  • Shu, Q.; Frieden, C.
    Relation of enzyme activity to local/global stability of murine adenosine deaminase: 19F NMR studies (2005), J. Mol. Biol., 345, 599-610.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 6-fluoro-D,L-tryptophan adenosine analogue, induces conformational changes inhibiting the enzyme, structural mechanism, overview Mus musculus
3.5.4.4 adenosine analogues induce conformational changes inhibiting the enzyme, structural mechanism, overview Mus musculus
3.5.4.4 additional information loss of activity precedes the global secondary and tertiary structure transition when the enzyme is exposed to denaturant, structural mechanism, overview Mus musculus
3.5.4.4 purine riboside adenosine analogue, induces conformational changes inhibiting the enzyme, structural mechanism, overview Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.4 additional information
-
 additional information thermodynamics and kinetics Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.4 Zn2+ zinc-metalloenzyme, binding structure Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.4 adenosine + H2O Mus musculus the enzyme is crucial for purine metabolism and normal immune competence inosine + NH3
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Mus musculus P03958
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
 Mus musculus inosine + NH3
-
 ir
3.5.4.4 adenosine + H2O the enzyme is crucial for purine metabolism and normal immune competence Mus musculus inosine + NH3
-
 ir

Subunits

EC Number Subunits Comment Organism
3.5.4.4 More the enzyme has (beta/alpha)8-barrel structure with bound zinc Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.5.4.4 ADA
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.4 20
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 7.4
-
 assay at Mus musculus