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Literature summary extracted from

  • Nguyen, C.; Ruda, G.F.; Schipani, A.; Kasinathan, G.; Leal, I.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L.M.; Sahlberg, B.L.; Johansson, N.G.; Gonzalez-Pacanowska, D.; Gilbert, I.H.
    Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (2006), J. Med. Chem., 49, 4183-4195.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 expression in Escherichia coli Homo sapiens
3.6.1.23 expression in Escherichia coli Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 1-(3-tert-butyldimethylsilyloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 1-(3-tert-butyldimethylsilyloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(3-triphenylsilyloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 1-(3-triphenylsilyloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(3-tritylaminopropyl)uracil
-
 Homo sapiens
3.6.1.23 1-(3-tritylaminopropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(3-trityloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 1-(3-trityloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(5-triphenylsilyloxypentyl)uracil
-
 Homo sapiens
3.6.1.23 1-(5-triphenylsilyloxypentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(5-tritylaminopentyl)uracil
-
 Homo sapiens
3.6.1.23 1-(5-tritylaminopentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-(5-trityloxypentyl)uracil
-
 Homo sapiens
3.6.1.23 1-(5-trityloxypentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 1-[(E)-4-trityloxy-2-butenyl]uracil
-
 Homo sapiens
3.6.1.23 1-[(E)-4-trityloxy-2-butenyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[(Z)-4-trityloxy-2-butenyl]uracil
-
 Homo sapiens
3.6.1.23 1-[(Z)-4-trityloxy-2-butenyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[2-(azidomethyl)-4-(trityloxy)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[2-(azidomethyl)-4-(trityloxy)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[2-(trityloxy)ethoxymethyl]uracil
-
 Homo sapiens
3.6.1.23 1-[2-(trityloxy)ethoxymethyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[4-(tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[4-(tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[4-acetoxy-3-(tritylaminomethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[4-acetoxy-3-(tritylaminomethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[4-hydroxy-2-(trityloxymethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[4-hydroxy-2-(trityloxymethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 additional information growth inhibition potency in vitro, overview, molecular docking modeling study Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+
-
 Homo sapiens
3.6.1.23 Mg2+
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Homo sapiens
-
 dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Plasmodium falciparum
-
 dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Homo sapiens
-
-
-
3.6.1.23 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.23 recombinant enzyme from Escherichia coli by phosphocellulose chromatography and gel filtration to near homogeneity Homo sapiens
3.6.1.23 recombinant enzyme from Escherichia coli by phosphocellulose chromatography and gel filtration to near homogeneity Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Plasmodium falciparum dUMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTPase
-
 Homo sapiens
3.6.1.23 dUTPase
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.23 0.0002
-
 1-(3-tritylaminopropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.00024
-
 1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0006
-
 1-[(E)-4-trityloxy-2-butenyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0007
-
 1-[2-(trityloxy)ethoxymethyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0009
-
 1-[4-hydroxy-2-(trityloxymethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0012
-
 1-[(Z)-4-trityloxy-2-butenyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0013
-
 1-[4-acetoxy-3-(tritylaminomethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0014
-
 1-(3-tritylaminopropyl)uracil
-
 Homo sapiens
3.6.1.23 0.0016
-
 1-(3-triphenylsilyloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.002
-
 1-(5-trityloxypentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.0022
-
 1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0025
-
 1-[4-(tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.0038
-
 1-(5-triphenylsilyloxypentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.0043
-
 1-(5-tritylaminopentyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.0052
-
 1-[(Z)-4-trityloxy-2-butenyl]uracil
-
 Homo sapiens
3.6.1.23 0.0057
-
 1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 0.017
-
 1-[2-(trityloxy)ethoxymethyl]uracil
-
 Homo sapiens
3.6.1.23 0.021
-
 1-[4-hydroxy-2-(trityloxymethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 0.023
-
 1-[2-(azidomethyl)-4-(trityloxy)butyl]uracil
-
 Plasmodium falciparum
3.6.1.23 0.025
-
 1-(3-triphenylsilyloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 0.073
-
 1-(3-tert-butyldimethylsilyloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 0.073
-
 1-(3-tert-butyldimethylsilyloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.074
-
 1-[4-acetoxy-3-(tritylaminomethyl)butyl]uracil
-
 Homo sapiens
3.6.1.23 0.087
-
 1-(3-trityloxypropyl)uracil
-
 Plasmodium falciparum
3.6.1.23 0.26
-
 1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil
-
 Homo sapiens
3.6.1.23 0.313
-
 1-(3-trityloxypropyl)uracil
-
 Homo sapiens
3.6.1.23 1
-
 1-(5-trityloxypentyl)uracil above Homo sapiens
3.6.1.23 1
-
 1-(5-tritylaminopentyl)uracil above Homo sapiens
3.6.1.23 1
-
 1-(5-triphenylsilyloxypentyl)uracil above Homo sapiens
3.6.1.23 1
-
 1-[(E)-4-trityloxy-2-butenyl]uracil above Homo sapiens
3.6.1.23 1
-
 1-[4-(tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]uracil above Homo sapiens
3.6.1.23 1
-
 1-[2-(azidomethyl)-4-(trityloxy)butyl]uracil above Homo sapiens