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Literature summary extracted from
- Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins (2005), J. Med. Chem., 48, 7781-7788.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.5.5 | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]butyl ester | IC50: 0.061 mM | Ovis aries |  |
| 3.6.5.5 | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]ethyl ester | IC50: 0.042 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]propyl ester | IC50: 0.038 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[2-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]ethyl]-3-(3,4,5-trihydroxyphenyl)acrylamide | IC50: 0.0017 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[2-[2-cyano-3-(3,4-dihydroxy-4-methoxyphenyl)acryloylamino]ethyl]-3-(3,4-dihydroxy-5-methoxyphenyl) acrylamide | IC50: 0.009 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]hexyl]-3-(3,4,5-trihydroxyphenyl)acrylamide | IC50: 0.006 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]hexyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | IC50: 0.08 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]pentyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | IC50: 0.008 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]butyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | IC50: 0.008 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]propyl]-3-(3,4-dihydroxy-5-meth-oxyphenyl)acrylamide | IC50: 0.005 mM | Ovis aries | |
| 3.6.5.5 | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)acrylamide | IC50: 0.0051 mM | Ovis aries | |
| 3.6.5.5 | catechol-acrylamide | IC50: 0.0051 mM | Ovis aries | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.5.5 | GTP + H2O | Ovis aries | GTPase is required for endocytosis | GDP + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.5.5 | Ovis aries | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.5.5 | brain | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.5.5 | GTP + H2O | - |
Ovis aries | GDP + phosphate | - |
? | |
| 3.6.5.5 | GTP + H2O | GTPase is required for endocytosis | Ovis aries | GDP + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.5.5 | dynamin I | - |
Ovis aries |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.6.5.5 | 0.0017 | - |
IC50: 0.0017 mM | Ovis aries | 2-cyano-N-[2-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]ethyl]-3-(3,4,5-trihydroxyphenyl)acrylamide | |
| 3.6.5.5 | 0.005 | - |
IC50: 0.005 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]propyl]-3-(3,4-dihydroxy-5-meth-oxyphenyl)acrylamide | |
| 3.6.5.5 | 0.0051 | - |
IC50: 0.0051 mM | Ovis aries | catechol-acrylamide | |
| 3.6.5.5 | 0.0051 | - |
IC50: 0.0051 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)acrylamide | |
| 3.6.5.5 | 0.006 | - |
IC50: 0.006 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]hexyl]-3-(3,4,5-trihydroxyphenyl)acrylamide | |
| 3.6.5.5 | 0.008 | - |
IC50: 0.008 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]butyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | |
| 3.6.5.5 | 0.008 | - |
IC50: 0.008 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]pentyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | |
| 3.6.5.5 | 0.009 | - |
IC50: 0.009 mM | Ovis aries | 2-cyano-N-[2-[2-cyano-3-(3,4-dihydroxy-4-methoxyphenyl)acryloylamino]ethyl]-3-(3,4-dihydroxy-5-methoxyphenyl) acrylamide | |
| 3.6.5.5 | 0.038 | - |
IC50: 0.038 mM | Ovis aries | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]propyl ester | |
| 3.6.5.5 | 0.042 | - |
IC50: 0.042 mM | Ovis aries | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]ethyl ester | |
| 3.6.5.5 | 0.061 | - |
IC50: 0.061 mM | Ovis aries | 2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]butyl ester | |
| 3.6.5.5 | 0.08 | - |
IC50: 0.08 mM | Ovis aries | 2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]hexyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide | |
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