Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L.
    Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase (2005), J. Med. Chem., 48, 4670-4678.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.3.18 medicine in vivo administration of DDAH inhibitors (2-amino-4-(NG-methyl-guanidino)butanoic acid and its analogues) increases plasma NG,NG-dimethyl-L-arginine levels, giving proof of concept that these can be used to probe the physiological effects of DDAH inhibition, with potential for pharmaceutical use of DDAH inhibitors in diseases where excess NO production is implicated Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 2-amino-4-(NG-methyl-guanidino)butanoic acid a series of analogues designed, reversible DDAH inhibitors Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.18 NG,NG-dimethyl-L-arginine + H2O Rattus norvegicus
-
 L-citrulline + dimethylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.18 blood
-
 Rattus norvegicus
-
3.5.3.18 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 NG,NG-dimethyl-L-arginine + H2O
-
 Rattus norvegicus L-citrulline + dimethylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH
-
 Rattus norvegicus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Rattus norvegicus