Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wnuk, S.F.; Lewandowska, E.; Sacasa, P.R.; Crain, L.N.; Zhang, J.; Borchardt, R.T.; De Clercq, E.
    Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects (2004), J. Med. Chem., 47, 5251-5257.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 9-[5,6,7,8-tetradeoxy-8-iodo-beta-D-ribo-oct-5(E)-en-7-yno-furanosyl]adenine
-
 Homo sapiens
3.13.2.1 9-[5,6,7,8-tetradeoxy-beta-D-ribo-oct-5(E)-en-7-ynofuranosyl]adenine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Homo sapiens
-
 recombinant
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 DL-homocysteine + adenosine
-
 Homo sapiens S-adenosyl-DL-homocysteine + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.13.2.1 0.00055
-
 9-[5,6,7,8-tetradeoxy-beta-D-ribo-oct-5(E)-en-7-ynofuranosyl]adenine 37°C, pH 7.2 Homo sapiens
3.13.2.1 0.1185
-
 9-[5,6,7,8-tetradeoxy-8-iodo-beta-D-ribo-oct-5(E)-en-7-yno-furanosyl]adenine 37°C, pH 7.2 Homo sapiens