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Literature summary extracted from

  • Owen, C.A.; Hu, Z.; Lopez-Otin, C.; Shapiro, S.D.
    Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase (2004), J. Immunol., 172, 7791-7803.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.34 additional information resistant to inhibition by tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.34 cell surface binding of MMP-8 to the surface of polymorphonuclear cells promotes stability Homo sapiens 9986
-
3.4.24.34 membrane
-
 Homo sapiens 16020
-
3.4.24.34 membrane membrane-bound MMP-8 accounts for 92% of the matrix metalloproteinase-mediated polymorphonuclear cell surface type I collagenase activity Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.34 Homo sapiens
-
-
-
3.4.24.34 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.34 polymorphonuclear cell MMP-8 is expressed in an inducible manner in both pro- and active forms on the surface of polymorphonuclear cell Homo sapiens
-
3.4.24.34 polymorphonuclear cell TIMP(tissue inhibitor of metalloproteinase)-resistant, active MMP-8 expressed on the surface of activated polymorphonuclear cells is likely to be an important form of MMP-8, regulating the lung inflammation and collagen turnover in vivo Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.34 alpha1-proteinase inhibitor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.34 Collagen + H2O type I and type II Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.34 metalloproteinase-8
-
 Mus musculus
3.4.24.34 metalloproteinase-8
-
 Homo sapiens
3.4.24.34 MMP-8
-
 Mus musculus
3.4.24.34 MMP-8
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.24.34 37
-
 t1/2 for soluble MMP-8: 7.5 h, membrane-bound MMP-8 retains more than 80% of its activity after 18 h. Binding of MMP-8 to the surface of polymorphonuclear cells promotes stability Homo sapiens