Literature summary extracted from

Ito, M.; Akai, E.; Izuka, M.; Segawa, H.; Kuwahata, M.; Miyamoto, K.
Cloning and characterization of three PHEX homologues in Drosophila (2004), J. Bone Miner. Metab., 22, 3-11.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.B15	dPHEX1-3, localization on the X-chromosome, genomic organization, DNA and amino acid sequence determination and analysis, expression profiles of the isozymes in embryonic developmental stages, expression of FLAG-tagged isozymes in S2 cells	Drosophila melanogaster

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.24.B15	additional information	dPHEX1 inactivation by P-element insertion, homozygous mutant fly embryos show complete lethality in the early stages	Drosophila melanogaster

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.24.B15	endoplasmic reticulum	isozymes dPHEX1 and dPHEX2	Drosophila melanogaster	5783	-
3.4.24.B15	Golgi apparatus	isozymes dPHEX1 and dPHEX2	Drosophila melanogaster	5794	-
3.4.24.B15	plasma membrane	isozymes dPHEX3 and dPHEX2	Drosophila melanogaster	5886	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B15	Drosophila melanogaster	-	three isozymes dPHEX1-3	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.B15	embryo	expression profiles of isozymes dPHEX1-3, dPHEX1 and dPHEX3 expression levels increase in late embryonic developmental stages, while dPHEX2 remains unaltered during the whole development	Drosophila melanogaster	-
3.4.24.B15	S2 cell	isozymes dPHEX1-3	Drosophila melanogaster	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B15	dPHEX	-	Drosophila melanogaster
3.4.24.B15	PHEX homologue	-	Drosophila melanogaster

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Release 2023.1 (January 2023)