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Literature summary extracted from

  • Ramana, K.V.; Fadl, A.A.; Tammali, R.; Reddy, A.B.; Chopra, A.K.; Srivastava, S.K.
    Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages (2006), J. Biol. Chem., 281, 33019-33029.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.21 medicine inhibition of AR may be a significant therapeutic approach in preventing bacterial endotoxin-induced sepsis and tissue damage Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 additional information inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview Mus musculus
1.1.1.21 sorbinil
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NADPH + H+ Mus musculus the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview alditol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 macrophage
-
 Mus musculus
-
1.1.1.21 RAW-264.7 cell macrophage cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 aldose + NADPH + H+
-
 Mus musculus alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview Mus musculus alditol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 AKR1B3
-
 Mus musculus
1.1.1.21 aldose reductase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 7.5
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Mus musculus