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Literature summary extracted from

  • Reinert, R.B.; Oberle, L.M.; Wek, S.A.; Bunpo, P.; Wang, X.P.; Mileva, I.; Goodwin, L.O.; Aldrich, C.J.; Durden, D.L.; McNurlan, M.A.; Wek, R.C.; Anthony, T.G.
    Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase (2006), J. Biol. Chem., 281, 31222-31233.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.1 medicine L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric and adult forms of acute lymphoblastic leukemia, ALL Escherichia coli
3.5.1.1 medicine L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric andadult forms of acute lymphoblastic leukemia, ALL Wolinella succinogenes

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.1 additional information applicated to mice, the enzyme abolishes serum asparagine and glutamine, and reduces protein synthesis in liver, and spleen, but not in pancreas via increase dephosphorylation of the translation factor eIF2, overview Escherichia coli
3.5.1.1 additional information applicated to mice, the enzyme abolishes serum asparagine, but not glutamine, the enzyme does not alter protein synthesis, overview Wolinella succinogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.1 L-asparagine + H2O Escherichia coli
-
 L-aspartate + NH3
-
 ?
3.5.1.1 L-asparagine + H2O Wolinella succinogenes
-
 L-aspartate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.1 Escherichia coli
-
-
-
3.5.1.1 Wolinella succinogenes
-
-
-
6.3.5.4 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.1
-
 Wolinella succinogenes
3.5.1.1 further purification of the commercial preparation by gel filtration to remove endotoxin Escherichia coli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.1 commercial preparation
-
 Escherichia coli
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.1 L-asparagine + H2O
-
 Escherichia coli L-aspartate + NH3
-
 ?
3.5.1.1 L-asparagine + H2O
-
 Wolinella succinogenes L-aspartate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.1 L-asparaginase
-
 Escherichia coli
3.5.1.1 L-asparaginase
-
 Wolinella succinogenes
6.3.5.4 L-asparaginase
-
 Escherichia coli