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Literature summary extracted from
- Generation of a stable activated thrombin activable fibrinolysis inhibitor variant (2006), J. Biol. Chem., 281, 15878-15883.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | S305C/T329I | generation of a stable activated thrombin activable fibrinolysis inhibitor variant by site-directed mutagenesis, the mutant's half-life is 11fold increased compared to the wild-type enzyme, the mutant also shows about 3fold higher fibrin clot lysis activityoverview | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.17.20 | extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | additional information | Homo sapiens | the activated enzyme shows anti-fibrinolytic and fibrin clot lysis activity | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | Homo sapiens | - |
wild-type isozymes A147/T325 and A147/I325 | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | proteolytic modification | activation of TAFI to TAFIa by cleavage through thrombin, activation reaction kinetics with wild-type isozymes and mutant enzymes at 37°C and pH 7.4 | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | hippuryl-L-arginine + H2O | - |
Homo sapiens | hippuric acid + L-arginine | - |
? | |
| 3.4.17.20 | additional information | the activated enzyme shows anti-fibrinolytic and fibrin clot lysis activity | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | activated thrombin activable fibrinolysis inhibitor | - |
Homo sapiens |
| 3.4.17.20 | TAFI | - |
Homo sapiens |
| 3.4.17.20 | TAFIa | - |
Homo sapiens |
| 3.4.17.20 | thrombin activable fibrinolysis inhibitor | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | 22 | 25 | assay at | Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | additional information | - |
the activated enzyme is thermolabile and inactivated through a conformational change | Homo sapiens |
| 3.4.17.20 | 37 | - |
half-life of wild-type TAFIa is 9.4 min, half-life of TAFIa mutant S305C/T329I is 70 min | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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