Literature summary extracted from

Guo, K.; Lukacik, P.; Papagrigoriou, E.; Meier, M.; Lee, W.H.; Adamski, J.; Oppermann, U.
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase (2006), J. Biol. Chem., 281, 10291-10297.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.1.1.30	sitting drop vapor diffusion method at 20°C, structure determined at a resolution of 1.8 A in complex with NAD(H)	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.30	0.0598	-	NAD+	25°C, pH 9.0	Homo sapiens
1.1.1.30	9.1	-	(R)-3-hydroxybutanoate	30°C, pH 9.0	Homo sapiens
1.1.1.30	10.5	-	(R)-3-hydroxybutanoate	25°C, pH 9.0	Homo sapiens
1.1.1.30	12.6	-	(R)-3-hydroxybutanoate	25°C, pH 7.5	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.30	cytosol	-	Homo sapiens	5829	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.30	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.30	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.30	HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.30	(R)-3-hydroxybutanoate + NAD+	-	Homo sapiens	acetoacetate + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.30	beta-hydroxybutyrate dehydrogenase	-	Homo sapiens
1.1.1.30	DHRS6	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.30	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)