Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kubota, K.; Nishii, W.; Kojima, M.; Takahashi, K.
    Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide (2005), J. Biol. Chem., 280, 999-1006.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.19 synthetic propeptides wild-type sequence Ala1-Asn41 and diverse truncated or mutated propeptides, overview, Ala1-Asn41 shows specific competitive inhibition, while mutants, especially R19A and H20A, show weak inhibitory effects, detailed overview Aspergillus niger var. macrosporus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.19 additional information
-
additional information kinetics, thermodynamics, overview Aspergillus niger var. macrosporus

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.19 Aspergillus niger var. macrosporus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.19 proteolytic modification the enzyme is synthesized as preproform and performs autoprocessing to the mature enzyme removing the 41-amino acid propeptide and an 11-amino acid intervening peptide Aspergillus niger var. macrosporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.19 angiotensin II + H2O
-
Aspergillus niger var. macrosporus DRVYIH + Pro-Phe
-
?
3.4.23.19 substance P + H2O
-
Aspergillus niger var. macrosporus RPKPQQFF + Gly-Leu-Met
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.19 AGP
-
Aspergillus niger var. macrosporus
3.4.23.19 aspergilloglutamic peptidase
-
Aspergillus niger var. macrosporus
3.4.23.19 More the enzyme belongs to the G1 peptidase family Aspergillus niger var. macrosporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.19 30
-
assay at Aspergillus niger var. macrosporus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.23.19 additional information
-
thermal stability overview, kinetics, thermodynamics, thermal unfolding is reversible at pH 5.0-6.0, overview, the wild-type propeptide stabilizes the enzyme, effects of truncated or mutated propeptides, overview Aspergillus niger var. macrosporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.19 4
-
assay at Aspergillus niger var. macrosporus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.23.19 additional information
-
pH profile Aspergillus niger var. macrosporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.23.19 additional information
-
additional information inhibition kinetics of truncated or mutated propeptides, detailed overview Aspergillus niger var. macrosporus
3.4.23.19 0.000027
-
synthetic propeptide Ala1-Asn24 pH 4.0, 30°C Aspergillus niger var. macrosporus