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Literature summary extracted from

  • Hambleton, R.; Krall, J.; Tikishvili, E.; Honeggar, M.; Ahmad, F.; Manganiello, V.C.; Movsesian, M.A.
    Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium (2005), J. Biol. Chem., 280, 39168-39174.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 3',5'-cGMP
-
 Homo sapiens
3.1.4.17 cilostazol
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.000079
-
 3',5'-cAMP isoform PDE3A-94 Homo sapiens
3.1.4.17 0.000088
-
 3',5'-cAMP isoform PDE3A-136 Homo sapiens
3.1.4.17 0.000093
-
 3',5'-cAMP isoform PDE3A-118 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O Homo sapiens inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium 5'-AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 myocardium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3.1.4.17 3',5'-cAMP + H2O inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 cyclic nucleotide phosphodiesterase PDE3
-
 Homo sapiens
3.1.4.17 PDE3
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.4.17 0.48
-
 3',5'-cAMP isoform PDE3A-136 Homo sapiens
3.1.4.17 0.5
-
 3',5'-cAMP isoform PDE3A-118 Homo sapiens
3.1.4.17 0.52
-
 3',5'-cAMP isoform PDE3A-94 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.17 0.00002
-
 3',5'-cGMP isoform PDE3A-118 Homo sapiens
3.1.4.17 0.000028
-
 3',5'-cGMP isoform PDE3A-94 Homo sapiens
3.1.4.17 0.00003
-
 3',5'-cGMP isoform PDE3A-136 Homo sapiens
3.1.4.17 0.000039
-
 cilostazol isoform PDE3A-118 Homo sapiens
3.1.4.17 0.00005
-
 cilostazol isoform PDE3A-136 Homo sapiens
3.1.4.17 0.000056
-
 cilostazol isoform PDE3A-94 Homo sapiens