Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Backlund, M.G.; Mann, J.R.; Holla, V.R.; Buchanan, F.G.; Tai, H.H.; Musiek, E.S.; Milne, G.L.; Katkuri, S.; DuBois, R.N.
    15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer (2005), J. Biol. Chem., 280, 3217-3223.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.141 additional information enzyme expression is inducible by indomethacin in LS174T cells, but not in HCA-7 and HCT-15 cells, and also not in enzyme-deficient HCT-116 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus PGE2 degradation (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens PGE2 degradation (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
 gene 15-Pgdh
-
1.1.1.141 Mus musculus
-
 gene 15-Pgdh
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 bladder
-
 Homo sapiens
-
1.1.1.141 colorectal cancer cell the enzyme expression is down-regulated Homo sapiens
-
1.1.1.141 DLD-1 cell low enzyme expression level Homo sapiens
-
1.1.1.141 embryo low enzyme expression level Mus musculus
-
1.1.1.141 HCA-7 cell low enzyme expression level Homo sapiens
-
1.1.1.141 HCT-15 cell
-
 Homo sapiens
-
1.1.1.141 HT-29 cell very low enzyme expression level Homo sapiens
-
1.1.1.141 kidney very low expression level Homo sapiens
-
1.1.1.141 kidney low enzyme expression level Mus musculus
-
1.1.1.141 liver
-
 Homo sapiens
-
1.1.1.141 liver high enzyme expression level Mus musculus
-
1.1.1.141 LoVo cell
-
 Homo sapiens
-
1.1.1.141 LS174T cell very low enzyme expression level Homo sapiens
-
1.1.1.141 lung
-
 Homo sapiens
-
1.1.1.141 lung high enzyme expression level Mus musculus
-
1.1.1.141 additional information distribution of enzyme expression in normal and pathological tissues, overview, no enzyme expression in spleen, heart, HCT-116 cells, CacO-2 cells and Colo 201 cells Homo sapiens
-
1.1.1.141 additional information tissue distribution of enzyme expression, overview, no expression in heart and brain Mus musculus
-
1.1.1.141 ovary low enzyme expression level Mus musculus
-
1.1.1.141 prostate gland very low expression level Homo sapiens
-
1.1.1.141 small intestine
-
 Homo sapiens
-
1.1.1.141 spleen low enzyme expression level Mus musculus
-
1.1.1.141 SW-480 cell very low enzyme expression level Homo sapiens
-
1.1.1.141 testis very low enzyme expression level Mus musculus
-
1.1.1.141 thymus low enzyme expression level Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ PGE2 degradation Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ PGE2 degradation Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or PGE2 Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Mus musculus
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens
1.1.1.141 15-PGDH
-
 Mus musculus
1.1.1.141 15-PGDH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Mus musculus
1.1.1.141 NAD+
-
 Homo sapiens