Literature summary extracted from

Kasus-Jacobi, A.; Ou, J.; Birch, D.G.; Locke, K.G.; Shelton, J.M.; Richardson, J.A.; Murphy, A.J.; Valenzuela, D.M.; Yancopoulos, G.D.; Edwards, A.O.
Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo (2005), J. Biol. Chem., 280, 20413-20420.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.300	cloned as a gene regulated by the transcription factor sterol regulatory element binding proteins and previously named SCALD for short chain aldehyde reductase	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.300	photoreceptor outer segment	-	Homo sapiens	1750	-
1.1.1.300	photoreceptor outer segment	rod	Homo sapiens	1750	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.300	Homo sapiens	O75911	-	-
1.1.1.300	Homo sapiens	Q8TC12	-	-
1.1.1.300	Homo sapiens	Q92781	-	-
1.1.1.300	Homo sapiens	Q96NR8	-	-
1.1.1.300	Homo sapiens	Q9HBH5	-	-
1.1.1.300	Homo sapiens	Q9NYR8	-	-
1.1.1.300	Mus musculus	Q9QYF1	mouse monoclonal anti-GRK1 (G-proteinassociated rhodopsin kinase-1)	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.300	eye	-	Homo sapiens	-
1.1.1.300	eye	-	Mus musculus	-
1.1.1.300	photoreceptor	-	Homo sapiens	-
1.1.1.300	photoreceptor	inner segment	Mus musculus	-
1.1.1.300	retinal pigment epithelium	-	Homo sapiens	-
1.1.1.300	retinal pigment epithelium	in vivo	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.300	11-cis-retinal + NADPH + H+	-	Homo sapiens	11-cis-retinol + NADP+	-	r
1.1.1.300	11-cis-retinal + NADPH + H+	The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11	Mus musculus	11-cis-retinol + NADP+	-	ir
1.1.1.300	11-cis-retinol + NADP+	-	Homo sapiens	11-cis-retinal + NADPH	-	?
1.1.1.300	all-trans-retinal + NADPH + H+	-	Homo sapiens	all-trans-retinol + NADP+	-	r
1.1.1.300	all-trans-retinal + NADPH + H+	-	Homo sapiens	all-tans-retinol + NADP+	-	r
1.1.1.300	all-trans-retinal + NADPH + H+	The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11	Mus musculus	all-tans-retinol + NADP+	-	ir

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.300	hRDH5	-	Homo sapiens
1.1.1.300	mouse RDH11	-	Mus musculus
1.1.1.300	mRDH11	-	Mus musculus
1.1.1.300	RDH12	-	Homo sapiens
1.1.1.300	RDH14	-	Homo sapiens
1.1.1.300	retSDR1	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.300	NADP+	-	Homo sapiens
1.1.1.300	NADP+	-	Mus musculus
1.1.1.300	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)