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Literature summary extracted from

  • Bonin, F.; Ryan, S.D.; Migahed, L.; Mo, F.; Lallier, J.; Franks, D.J.; Arai, H.; Bennett, S.A.
    Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit (2004), J. Biol. Chem., 279, 52425-52436.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.47 medicine potential use of PAF-AH alpha2 as pharmacologically active protein to promote cell survival Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 5,5'-dithiobis-2-nitrobenzoic acid
-
 Rattus norvegicus
3.1.1.47 diisopropyl fluorophosphates
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Rattus norvegicus regulation of platelet-activating factor, anti apoptotic protein 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Rattus norvegicus P83006 3 months old Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 brain
-
 Rattus norvegicus
-
3.1.1.47 PC12-AC cell clonal derivative of PC12 cell line Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor, anti apoptotic protein Rattus norvegicus 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.47 dimer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF acetylhydrolase I
-
 Rattus norvegicus
3.1.1.47 PAF acetylhydrolase II
-
 Rattus norvegicus
3.1.1.47 PAF-AH I
-
 Rattus norvegicus
3.1.1.47 PAF-AH II
-
 Rattus norvegicus