EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.41 | chondroitin-4-sulfate | activates apoB-100/LDL degradation by cathepsin F | Homo sapiens | |
3.4.22.41 | chondroitin-6-sulfate | activates apoB-100/LDL degradation by cathepsin F | Homo sapiens | |
3.4.22.41 | dermatan sulfate | activates apoB-100/LDL degradation by cathepsin F | Homo sapiens | |
3.4.22.41 | heparan sulfate | activates apoB-100/LDL degradation by cathepsin F | Homo sapiens | |
3.4.22.41 | human aortic proteoglycans | activates apoB-100/LDL degradation by cathepsin F | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.22.41 | expression of mature enzyme in Escherichia coli | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.22.41 | extracellular | secretion of the enzyme by macrophage cell culture | Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.41 | additional information | Homo sapiens | the enzyme is a cysteine protease | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.41 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.41 | macrophage | monocyte-derived cell culture, enzyme is secreted | Homo sapiens | - |
3.4.22.41 | additional information | expression mainly in coronary atherosclerotic plaques | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.41 | apoB-100 + H2O | apoB-100 is part of LDL particles | Homo sapiens | ? | - |
? | |
3.4.22.41 | additional information | the enzyme is a cysteine protease | Homo sapiens | ? | - |
? | |
3.4.22.41 | additional information | the enzyme is a cysteine protease and modifies low density lipoprotein particles in vitro | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.41 | CatF | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.22.41 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.41 | 6 | - |
about | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.41 | additional information | - |
slightly acidic pH optimum, rapid inactivation at neutral pH | Homo sapiens |