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Literature summary extracted from

  • Bekesi, A.; Zagyva, I.; Hunyadi-Gulyas, E.; Pongracz, V.; Kovari, J.; Nagy, A.O.; Erdei, A.; Medzihradszky, K.F.; Vertessy, B.G.
    Developmental regulation of dUTPase in Drosophila melanogaster (2004), J. Biol. Chem., 279, 22362-22370.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 two isozymes, DNA and amino acid sequence determination and analysis, developmental expression analysis, overview Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.23 cytoplasm one isozyme might be located in the cytoplasm Drosophila melanogaster 5737
-
3.6.1.23 additional information subcellular localization study, no localization of the enzyme in mitochondria Drosophila melanogaster
-
-
3.6.1.23 nucleus one isozyme might be located in the nucleus Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Drosophila melanogaster the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Drosophila melanogaster
-
 two isozymes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.23 subcellular fractionation Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.23 embryo
-
 Drosophila melanogaster
-
3.6.1.23 larva reduced enzyme expression Drosophila melanogaster
-
3.6.1.23 additional information the enzyme is constitutively expressed in the adult fly Drosophila melanogaster
-
3.6.1.23 ovary
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O the enzyme prevents incorporation of uracil into DNA by strict regulation of the cellular dUTP to dTTP ratio, developmental regulation of the isozymes at mRNA and protein levels Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 More the enzyme interacts with several protein partners in the cell Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTPase
-
 Drosophila melanogaster