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Literature summary extracted from

  • Gao, G.; Plaas, A.; Thompson, V.P.; Jin, S.; Zuo, F.; Sandy, J.D.
    ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1 (2004), J. Biol. Chem., 279, 10042-10051.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.82 glycosylphosphatidyl inositolanchored membrane type 4-matrix metalloproteinase MT4-MMP or also called MMP-17 Homo sapiens
3.4.24.82 syndecan-1 proteoglycan form of syndecan-1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.82 E362Q inactive mutant, single point mutation (G to C) leading to the amino acid change at residue 362 located within the catalytic domain of ADAMTS4 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.82 2-deoxyfluoroglucose 0.01 mM Homo sapiens
3.4.24.82 D-mannosamine 1.5 mM Homo sapiens
3.4.24.82 additional information ADAMTS-4 is not inhibited by 125 nM or less tissue inhibitor of metalloproteinase-1 Homo sapiens
3.4.24.82 Tissue inhibitor of metalloproteinase-1 150 nM or 270 nM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.82 cell surface
-
 Homo sapiens 9986
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.82 64000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.82 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.82 chondrosarcoma cell line
-
 Homo sapiens
-
3.4.24.82 fibroblast cell line
-
 Homo sapiens
-
3.4.24.82 JJ012-TS4 cell
-
 Homo sapiens
-
3.4.24.82 VA13-TS4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.82 aggrecan + H2O
-
 Homo sapiens fragments of aggrecan
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.82 ADAMTS-4
-
 Homo sapiens
3.4.24.82 ADAMTS4 a disintegrin and metalloproteinase with thrombospondinlike motif 4 Homo sapiens
3.4.24.82 aggrecanase-1
-
 Homo sapiens