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Literature summary extracted from
- A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization (1990), J. Biol. Chem., 265, 5930-5933.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.119 | antipain | 2 mM, 100% inhibition | Mus musculus |  |
| 3.4.21.119 | benzamidine | 2 mM, 100% inhibition | Mus musculus | |
| 3.4.21.119 | diisopropyl fluorophosphate | 2 mM, 35% inhibition | Mus musculus | |
| 3.4.21.119 | leupeptin | 2 mM, 100% inhibition | Mus musculus | |
| 3.4.21.119 | additional information | not inhibitory: EDTA, iodoacetamide, aprotinin | Mus musculus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.119 | 10000 | - |
1 * 17000 + 1 * 10000, SDS-PAGE | Mus musculus |
| 3.4.21.119 | 17000 | - |
1 * 17000 + 1 * 10000, SDS-PAGE | Mus musculus |
| 3.4.21.119 | 27000 | - |
gel filtration, SDS-PAGE under nonreducing conditions | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.119 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.119 | submandibular gland | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.119 | additional information | no substrate: mouse prorenin Ren1, human prorenin | Mus musculus | ? | - |
? | |
| 3.4.21.119 | mouse prorenin Ren2 + H2O | specific cleavage of Lys-Arg bond of mouse prorenin Ren2 | Mus musculus | renin + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.119 | dimer | 1 * 17000 + 1 * 10000, SDS-PAGE | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.119 | prorenin converting enzyme | - |
Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.119 | 7.5 | 8.5 | - |
Mus musculus |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.21.119 | Mus musculus | - |
9.8 | 9.5 |
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