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Literature summary extracted from

  • Sebert, M.E.; Patel, K.P.; Plotnick, M.; Weiser, J.N.
    Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system (2005), J. Bacteriol., 187, 3969-3979.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.107 IPTG
-
 Streptococcus pneumoniae

Application

EC Number Application Comment Organism
3.4.21.107 additional information regulatory role for pneumococcal HtrA in modulating the activity of a two-component signaling system that controls the development of genetic competence Streptococcus pneumoniae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.107 expression in Escherichia coli as an IPTG-inducible, recombinant protein having both N-terminal and C-terminal His6-tags Streptococcus pneumoniae

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.107 additional information mutant P1149 containing an insertion deletion mutation in the caiRH locus resulting in substantially lower HtrA expression Streptococcus pneumoniae
3.4.21.107 S234A mutant P1386, release of competence inhibition when mutant P1388 is present alone Streptococcus pneumoniae
3.4.21.107 T230P mutant P1388 with ciaH mutation Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.107 additional information rHtrA-mediated decline in transformation efficiency can not be corrected with excess competence-stimulating peptide Streptococcus pneumoniae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.107 cell surface
-
 Streptococcus pneumoniae 9986
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.107 45000
-
 SDS-PAGE with coomassie staining Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Escherichia coli
-
-
-
3.4.21.107 Streptococcus pneumoniae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.107 by Ni affinity chromatography Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.107 beta-casein + H2O
-
 Streptococcus pneumoniae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 HtrA protease
-
 Streptococcus pneumoniae
3.4.21.107 HtrA/DegP
-
 Escherichia coli
3.4.21.107 serine protease
-
 Streptococcus pneumoniae