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Literature summary extracted from
- Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo (2006), J. Agric. Food Chem., 54, 6640-6644.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | drug development | the enzyme is a target for inhibitor design, enzyme inhibition has considerable potential for the treatment of diabetes, without increased risk of hypoglycemia | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | (4-hydroxy-3-methoxyphenyl)acetonitrile | IC50: 0.0244 mM | Homo sapiens |  |
| 1.1.1.21 | (4-hydroxy-3-methoxyphenyl)methamine | IC50: 0.0634 mM | Homo sapiens | |
| 1.1.1.21 | 2-(3,4-dimethoxyphenyl)-ethanoic acid | IC50: 0.0303 mM | Homo sapiens | |
| 1.1.1.21 | 2-(4-hydroxy-3-methoxyphenyl)ethanoic acid | derived from ginger rhizom, Zingiber officinale, IC50: 0.0185 mM, suppresses nt only sorbitol accumulation in human erythrocytes | Homo sapiens | |
| 1.1.1.21 | 2-(4-hydroxy-3-methoxyphenyl)ethanol | derived from ginger rhizom, Zingiber officinale, IC50: 0.0192 mM, suppresses sorbitol accumulation in human erythrocytes | Homo sapiens | |
| 1.1.1.21 | 3-(4-hydroxy-3-methoxyphenyl)propanol | IC50: 0.283 mM | Homo sapiens | |
| 1.1.1.21 | 4-(4-hydroxy-3-methoxyphenyl)-2-butanone | IC50: 0.197 mM | Homo sapiens | |
| 1.1.1.21 | 4-(4-hydroxy-3-methoxyphenyl)butanol | IC50: 0.642 mM | Homo sapiens | |
| 1.1.1.21 | 4-hydroxy-3-methoxyphenol | IC50: 0.273 mM | Homo sapiens | |
| 1.1.1.21 | 4-hydroxy-3-methoxyphenyl methanol | IC50: 0.0244 mM | Homo sapiens | |
| 1.1.1.21 | additional information | aldose reductase inhibitors have considerable potential for the treatment of diabetes, without increased risk of hypoglycemia, structure-activity relationship study, the applicable side alkyl chain length and the presence of a OCH3 group at C3 in the aromatic ring are essential features for enzyme recognition and binding, no or poor inhibition by gingerol, shogaol, 2-(4-hydroxy-3-nitrophenyl)ethanoic acid, 2-(3,4-dihydroxyphenyl)ethanoic acid, and 2-(4-hydroxyphenyl)ethanoic acid | Homo sapiens | |
| 1.1.1.21 | quercetin | IC50: 0.027 mM | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | commercial preparation | recombinant enzyme | Homo sapiens | - |
| 1.1.1.21 | erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | aldose reductase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 37 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | NADPH | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.21 | 0.0185 | - |
derived from ginger rhizom, Zingiber officinale, IC50: 0.0185 mM, suppresses nt only sorbitol accumulation in human erythrocytes | Homo sapiens | 2-(4-hydroxy-3-methoxyphenyl)ethanoic acid | |
| 1.1.1.21 | 0.0192 | - |
derived from ginger rhizom, Zingiber officinale, IC50: 0.0192 mM, suppresses sorbitol accumulation in human erythrocytes | Homo sapiens | 2-(4-hydroxy-3-methoxyphenyl)ethanol | |
| 1.1.1.21 | 0.0244 | - |
IC50: 0.0244 mM | Homo sapiens | 4-hydroxy-3-methoxyphenyl methanol | |
| 1.1.1.21 | 0.0244 | - |
IC50: 0.0244 mM | Homo sapiens | (4-hydroxy-3-methoxyphenyl)acetonitrile | |
| 1.1.1.21 | 0.027 | - |
IC50: 0.027 mM | Homo sapiens | quercetin | |
| 1.1.1.21 | 0.0303 | - |
IC50: 0.0303 mM | Homo sapiens | 2-(3,4-dimethoxyphenyl)-ethanoic acid | |
| 1.1.1.21 | 0.0634 | - |
IC50: 0.0634 mM | Homo sapiens | (4-hydroxy-3-methoxyphenyl)methamine | |
| 1.1.1.21 | 0.197 | - |
IC50: 0.197 mM | Homo sapiens | 4-(4-hydroxy-3-methoxyphenyl)-2-butanone | |
| 1.1.1.21 | 0.273 | - |
IC50: 0.273 mM | Homo sapiens | 4-hydroxy-3-methoxyphenol | |
| 1.1.1.21 | 0.283 | - |
IC50: 0.283 mM | Homo sapiens | 3-(4-hydroxy-3-methoxyphenyl)propanol | |
| 1.1.1.21 | 0.642 | - |
IC50: 0.642 mM | Homo sapiens | 4-(4-hydroxy-3-methoxyphenyl)butanol | |
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