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Literature summary extracted from

  • Dell'Agli, M.; Galli, G.V.; Vrhovsek, U.; Mattivi, F.; Bosisio, E.
    In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes (2005), J. Agric. Food Chem., 53, 1960-1965.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.35 expression of isoform PDE5A1 in COS-7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 delphinidin
-
 Homo sapiens
3.1.4.35 delphinidin 3-glucoside
-
 Homo sapiens
3.1.4.35 malvidin IC50: 0.0354 mM Homo sapiens
3.1.4.35 malvidin-3-O-beta-glucoside IC50: 0.0116 mM Homo sapiens
3.1.4.35 additional information red wine and extract from grape skin inhibit isoenzyme PDE5A1 activity, seed extract has negligible effect. Polyphenol-induced vasorelexation may be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. trans-Resveratrol and trans-piceid exhibit negligible effects. hydroxycinnamates are completely inactive Homo sapiens
3.1.4.35 peonidin
-
 Homo sapiens
3.1.4.35 peonidin 3-glucoside
-
 Homo sapiens
3.1.4.35 petunidin
-
 Homo sapiens
3.1.4.35 petunidin 3-glucoside
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 cGMP-specific phosphodiesterase-5
-
 Homo sapiens
3.1.4.35 PDE5A1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.35 0.0116
-
 IC50: 0.0116 mM Homo sapiens malvidin-3-O-beta-glucoside
3.1.4.35 0.0354
-
 IC50: 0.0354 mM Homo sapiens malvidin