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Literature summary extracted from

  • Xu, L.; Frucht, D.M.
    Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses (2007), Int. J. Biochem. Cell Biol., 39, 20-24.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.83 Zn2+ lethal factor along with its receptor-binding partner protective antigen, forms lethal toxin, a critical virulence factor for bacillus anthracis. Lethal factor is a Zn2+ protease Bacillus anthracis
3.4.24.83 Zn2+ Zn2+ protease Bacillus anthracis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.83 additional information Bacillus anthracis lethal factor acts directly on T and B lymphocytes, blocking antigen receptor-dependent proliferation, cytokine production and Ig production. In this manner, lethal factor mounts a broad-based attack on host-immunity, thus providing Bacillus anthracis with multiple mechanisms for avoiding protective host responses ?
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?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase kinase + H2O
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Bacillus anthracis ?
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?
3.4.24.83 additional information lethal factor acts directly on T and B lymphocytes, blocking antigen receptor-dependent proliferation, cytokine production and Ig production. In this manner, lethal factor mounts a broad-based attack on host-immunity, thus providing Bacillus anthracis with multiple mechanisms for avoiding protective host responses Bacillus anthracis ?
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?
3.4.24.83 additional information does not cleave MEK5 Bacillus anthracis ?
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?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal factor anthrax lethal factor along with its receptor-binding partner protective antigen forms anthrax lethal toxin Bacillus anthracis