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Literature summary extracted from

  • Wu, S.; Shin, J.; Zhang, G.; Cohen, M.; Franco, A.; Sears, C.L.
    The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor (2006), Infect. Immun., 74, 5382-5390.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.74 additional information intestinal epithelial cells in vitro possess a specific membrane BFT receptor that is distinct from E-cadherin Bacteroides fragilis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.74 H352Y Alexa-488-labeled BFT binding to HT29/C1 not blocked Bacteroides fragilis
3.4.24.74 additional information BFT-C4, which has reduced BFT biological activity, shows a significant decrease in HT29/C1 cell binding Bacteroides fragilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.74 germ agglutinin inhibits BFT biological activity on HT29/C1 cells but not binding of Alexa 488-labeled BFT to HT29/C1 cells Bacteroides fragilis
3.4.24.74 GM6001 significantly reduces Alexa 488-labeled BFT binding Bacteroides fragilis
3.4.24.74 additional information not inhibited by lectins, sugars or mixed bovine brain gangliosides Bacteroides fragilis
3.4.24.74 subtilisin A inhibits both BFT biological activity on HT29/C1 cells and nearly 90% of binding of Alexa 488-labeled BFT Bacteroides fragilis
3.4.24.74 Thermolysin inhibits both BFT biological activity on HT29/C1 cells and nearly 90% of binding of Alexa 488-labeled BFT Bacteroides fragilis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.74 Bacteroides fragilis
-
-
-
3.4.24.74 Bacteroides fragilis I-1345
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.74 purified to homogeneity by urea-based purification method Bacteroides fragilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.74 E-cadherin + H2O neither human nor rat E-cadherin are the cellular receptor for BFT Bacteroides fragilis ?
-
 ?
3.4.24.74 E-cadherin + H2O neither human nor rat E-cadherin are the cellular receptor for BFT Bacteroides fragilis I-1345 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.74 Bacteroides fragilis toxin
-
 Bacteroides fragilis
3.4.24.74 BFT
-
 Bacteroides fragilis