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Literature summary extracted from

  • Raupach, B.; Peuschel, S.K.; Monack, D.M.; Zychlinsky, A.
    Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar typhimurium infection (2006), Infect. Immun., 74, 4922-4926.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.36 interleukin-18 + H2O Mus musculus caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 ?
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 ?
3.4.22.36 interleukin-1beta + H2O Mus musculus caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.36 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.36 interleukin-18 + H2O caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 Mus musculus ?
-
 ?
3.4.22.36 interleukin-1beta + H2O caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 Mus musculus ?
-
 ?
3.4.22.36 pre-interleukin-18 + H2O
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 Mus musculus interleukin-18 + ?
-
 ?
3.4.22.36 pre-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.36 CASP-1
-
 Mus musculus