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Literature summary extracted from

  • Wu, S.; Powell, J.; Mathioudakis, N.; Kane, S.; Fernandez, E.; Sears, C.L.
    Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway (2004), Infect. Immun., 72, 5832-5839.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.74 medicine stimulates interleukin-8 secretion by human intestinal epithelial HT29/C1 cells, biological active BFT, but not serum, is required for interleukin-8 production, NF-kB, tyrosine kinase and mitogen activated protein kinase signaling pathways are involved in BFT-induced interleukin-8 stimulation Bacteroides fragilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.74 genistein broad spectrum tyrosine kinase inhibitor, significantly inhibits BFT-stimulated interleukin-8 production Bacteroides fragilis
3.4.24.74 PP2 selective Src-family tyrosine kinase inhibitor, significantly inhibits ca. 73% of BFT-stimulated interleukin-8 production Bacteroides fragilis
3.4.24.74 SB203580 p38 inhibitor, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production Bacteroides fragilis
3.4.24.74 tyrphostin AG1478 selective epidermal growth factor receptor tyrosine kinase inhibitor, significantly inhibits ca. 64% of BFT-stimulated interleukin-8 production Bacteroides fragilis
3.4.24.74 U126 inhibits both basal and BFT-augmented extracellular signal-related kinase phosphorylation, 0.01 mM inhibits ca. 80% of BFT-stimulated interleukin-8 production Bacteroides fragilis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.74 Bacteroides fragilis
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-
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3.4.24.74 Bacteroides fragilis 086-5443-2-2
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Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.74
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 Bacteroides fragilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
3.4.24.74 Baceroides fragilis enterotoxin
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 Bacteroides fragilis
3.4.24.74 Bacteroides fragilis toxin
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 Bacteroides fragilis
3.4.24.74 BFT
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 Bacteroides fragilis